BACKGROUND: We have investigated the differences between metabolically "healthy" morbidly obese patients and those with comorbidities. MATERIALS AND METHODS: Thirty-two morbidly obese patients were divided by the absence ("healthy": DM-DL-) or presence of comorbidities (dyslipidemic: DM-DL+, or dyslipidemic and with type 2 diabetes: DM+DL+). We have studied various plasma parameters and gene expression adipose tissue, before and after gastric bypass. RESULTS: The group DM+DL+ tends to have lower values than the other two groups for anthropometric parameters. Regarding the satiety parameters, only leptin (p = 0.0024) showed a significant increase with comorbidities. Lipid parameters showed significant differences among groups, except for phospholipids and NEFA. For insulin resistance parameters, only glucose (p < 0.0001) was higher in DM+DL+ patients, but not insulin or homeostasis model assessment of insulin resistance (HOMA-IR). The gene expression of adiponectin, insulin receptor (INSR) and glucose receptor-4 (GLUT4), in the subcutaneous fat, decreased in all groups vs. a non-obese control. Interleukin-6 (IL6) and the inhibitor of plasminogen activator type 1 (PAI-1) genes decreased only in DM-DL+ and DM+DL+, but not in "healthy" patients. Leptin increased in all groups vs. the non-obese control. The visceral fat from DM+DL+ patients showed a sharp decrease in adiponectin, GLUT4, IL6 and PAI-1. All parameters mentioned above improved very significantly by surgery, independent of the occurrence of comorbidities. CONCLUSIONS: The morbidly obese "healthy" individual is not really metabolically healthy, but morbidly obese individuals with diabetes and dyslipidemia are more metabolically imbalanced.
BACKGROUND: We have investigated the differences between metabolically "healthy" morbidly obesepatients and those with comorbidities. MATERIALS AND METHODS: Thirty-two morbidly obesepatients were divided by the absence ("healthy": DM-DL-) or presence of comorbidities (dyslipidemic: DM-DL+, or dyslipidemic and with type 2 diabetes: DM+DL+). We have studied various plasma parameters and gene expression adipose tissue, before and after gastric bypass. RESULTS: The group DM+DL+ tends to have lower values than the other two groups for anthropometric parameters. Regarding the satiety parameters, only leptin (p = 0.0024) showed a significant increase with comorbidities. Lipid parameters showed significant differences among groups, except for phospholipids and NEFA. For insulin resistance parameters, only glucose (p < 0.0001) was higher in DM+DL+ patients, but not insulin or homeostasis model assessment of insulin resistance (HOMA-IR). The gene expression of adiponectin, insulin receptor (INSR) and glucose receptor-4 (GLUT4), in the subcutaneous fat, decreased in all groups vs. a non-obese control. Interleukin-6 (IL6) and the inhibitor of plasminogen activator type 1 (PAI-1) genes decreased only in DM-DL+ and DM+DL+, but not in "healthy" patients. Leptin increased in all groups vs. the non-obese control. The visceral fat from DM+DL+ patients showed a sharp decrease in adiponectin, GLUT4, IL6 and PAI-1. All parameters mentioned above improved very significantly by surgery, independent of the occurrence of comorbidities. CONCLUSIONS: The morbidly obese "healthy" individual is not really metabolically healthy, but morbidly obese individuals with diabetes and dyslipidemia are more metabolically imbalanced.
Authors: Nuria Barbarroja; Rosario López-Pedrera; Maria Dolores Mayas; Eduardo García-Fuentes; Lourdes Garrido-Sánchez; M Macías-González; Rajaa El Bekay; Antonio Vidal-Puig; Francisco J Tinahones Journal: Biochem J Date: 2010-08-15 Impact factor: 3.857
Authors: Z Pataky; V Makoundou; P Nilsson; R S Gabriel; K Lalic; E Muscelli; A Casolaro; A Golay; E Bobbioni-Harsch Journal: Int J Obes (Lond) Date: 2011-01-04 Impact factor: 5.095
Authors: Rachel P Wildman; Robert Kaplan; JoAnn E Manson; Aleksandar Rajkovic; Stephanie A Connelly; Rachel H Mackey; Lesley F Tinker; J David Curb; Charles B Eaton; Sylvia Wassertheil-Smoller Journal: Obesity (Silver Spring) Date: 2011-01-13 Impact factor: 5.002
Authors: Nuria Barbarroja; Chary Lopez-Pedrera; Lourdes Garrido-Sanchez; Maria Dolores Mayas; Wilfredo Oliva-Olivera; Maria Rosa Bernal-Lopez; Rajaa El Bekay; Francisco Jose Tinahones Journal: PLoS One Date: 2012-10-24 Impact factor: 3.240
Authors: C Bañuls; S Rovira-Llopis; S Lopez-Domenech; N Diaz-Morales; A Blas-Garcia; S Veses; C Morillas; V M Victor; M Rocha; A Hernandez-Mijares Journal: Int J Obes (Lond) Date: 2017-06-20 Impact factor: 5.095
Authors: Eva Pardina; Roser Ferrer; Joana Rossell; Juan Antonio Baena-Fustegueras; Albert Lecube; Jose Manuel Fort; Enric Caubet; Óscar González; Ramón Vilallonga; Víctor Vargas; José María Balibrea; Julia Peinado-Onsurbe Journal: BBA Clin Date: 2016-01-08