PURPOSE: The aim of our study is to provide a precise quantification for the association between DNA methyltransferase 3B (DNMT3B) variations (rs2424913 C/T, rs1569686 G/T, rs6087990 T/C and rs2424908 T/C) and the risk of cancer. METHODS: We performed a systematic literature review and assessed the methodological quality of included case-control designed studies based on Newcastle-Ottawa Scale. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were calculated to assess the strengths of the associations. RESULTS: We identified 34 studies for pooled analyses. Overall, the results demonstrated that rs2424913 polymorphism was significantly associated with negative cancer risk in the African population (CT vs TT: OR 0.10, 95% CI 0.02-0.63, P = 0.01; CT+CC vs TT: OR 0.14, 95% CI 0.03-0.76, P = 0.02), and the rs1569686 polymorphism was significantly associated with a subtly decreased cancer risk (GT vs TT: OR 0.80, 95% CI 0.72-0.90, P < 0.01; GT+GG vs TT: OR 0.84, 95% CI 0.76-0.94, P < 0.01), particularly in the Asian population (GT vs TT: OR 0.79, 95% CI 0.66-0.96, P < 0.01) and in colorectal cancer subgroup (G vs T: OR 0.69, 95% CI 0.54-0.88, P < 0.01). In addition, the rs6087990 polymorphism was associated with decreased risk in Asian population (T vs C: OR 0.77, 95% CI 0.62-0.96, P = 0.02). Similarly, the rs2424908 polymorphism was observed as a protective factor for cancer in the Asian population (CT+CC vs TT: OR 0.79, 95% CI 0.66-0.95, P = 0.01). CONCLUSIONS: DNMT3B polymorphisms might be associated with decreased cancer risk especially in the Asian population and for colorectal cancer. Further multicentric studies are still needed to confirm the results.
PURPOSE: The aim of our study is to provide a precise quantification for the association between DNA methyltransferase 3B (DNMT3B) variations (rs2424913 C/T, rs1569686 G/T, rs6087990 T/C and rs2424908 T/C) and the risk of cancer. METHODS: We performed a systematic literature review and assessed the methodological quality of included case-control designed studies based on Newcastle-Ottawa Scale. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were calculated to assess the strengths of the associations. RESULTS: We identified 34 studies for pooled analyses. Overall, the results demonstrated that rs2424913 polymorphism was significantly associated with negative cancer risk in the African population (CT vs TT: OR 0.10, 95% CI 0.02-0.63, P = 0.01; CT+CC vs TT: OR 0.14, 95% CI 0.03-0.76, P = 0.02), and the rs1569686 polymorphism was significantly associated with a subtly decreased cancer risk (GT vs TT: OR 0.80, 95% CI 0.72-0.90, P < 0.01; GT+GG vs TT: OR 0.84, 95% CI 0.76-0.94, P < 0.01), particularly in the Asian population (GT vs TT: OR 0.79, 95% CI 0.66-0.96, P < 0.01) and in colorectal cancer subgroup (G vs T: OR 0.69, 95% CI 0.54-0.88, P < 0.01). In addition, the rs6087990 polymorphism was associated with decreased risk in Asian population (T vs C: OR 0.77, 95% CI 0.62-0.96, P = 0.02). Similarly, the rs2424908 polymorphism was observed as a protective factor for cancer in the Asian population (CT+CC vs TT: OR 0.79, 95% CI 0.66-0.95, P = 0.01). CONCLUSIONS:DNMT3B polymorphisms might be associated with decreased cancer risk especially in the Asian population and for colorectal cancer. Further multicentric studies are still needed to confirm the results.
Authors: Stefan de Vogel; Kim A D Wouters; Ralph W H Gottschalk; Frederik J van Schooten; Anton F P M de Goeij; Adriaan P de Bruïne; Royle A Goldbohm; Piet A van den Brandt; Matty P Weijenberg; Manon van Engeland Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-10-20 Impact factor: 4.254
Authors: Luo Wang; Marivonne Rodriguez; Edward S Kim; Yunling Xu; Neby Bekele; Adel K El-Naggar; Waun Ki Hong; Li Mao; Yun W Oh Journal: Int J Oncol Date: 2004-10 Impact factor: 5.650
Authors: Barry Iacopetta; Jane Heyworth; Jennifer Girschik; Fabienne Grieu; Cassandra Clayforth; Lin Fritschi Journal: Int J Cancer Date: 2009-07-01 Impact factor: 7.396
Authors: Oriana M Damas; Lissette Gomez; Maria A Quintero; Evadnie Rampersaud; Susan Slifer; Gary W Beecham; David H Kerman; Amar R Deshpande; Daniel A Sussman; Maria T Abreu; Jacob L McCauley Journal: Clin Transl Gastroenterol Date: 2017-04-13 Impact factor: 4.488
Authors: Salvatore Terrazzino; Letizia Deantonio; Sarah Cargnin; Laura Donis; Carla Pisani; Laura Masini; Giuseppina Gambaro; Pier Luigi Canonico; Armando A Genazzani; Marco Krengli Journal: Cancer Res Treat Date: 2016-08-23 Impact factor: 4.679
Authors: Tialfi Bergamin De Castro; Gabriela Helena Rodrigues-Fleming; Juliana Garcia De Oliveira-Cucolo; Jéssika Nunes Gomes Da Silva; Fabia Pigatti Silva; Luiz Sérgio Raposo; José Victor Maniglia; Erika Cristina Pavarino; Lidia Maria Rebolho Batista Arantes; Ana Lívia Silva Galbiatti-Dias; Eny Maria Goloni Bertollo Journal: Asian Pac J Cancer Prev Date: 2020-12-01