Agathe Bridoux1,2, Xavier Drouot3,4, Aude Sangare1,2, Tarik Al-Ani2, Arnaud Brignol5, Anais Charles-Nelson6, Pierre Brugières7, Gaëtane Gouello8, Koichi Hosomi8, Hélène Lepetit8, Stéphane Palfi8. 1. AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Physiologie Créteil, 94010, France. 2. Département de Physiologie, Hôpital Henri Mondor, Faculté de Médecine de Créteil, UPEC, Créteil, France. 3. CHU Poitiers, Service de Neurophysiologie Clinique, Pole Neurosciences, Poitiers, France. 4. Université de Poitiers, Faculté de Médecine et de Pharmacie, Poitiers, France. 5. DIRO, Université de Montréal, succursale Centre-Ville, Montréal (Québec), Canada. 6. AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Statistiques, Créteil, France. 7. AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Radiologie, Créteil, France. 8. AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Neurochirurgie, Unité de Neurochirurgie Fonctionnelle, Créteil, France.
Abstract
STUDY OBJECTIVES: To explore the influence of acute bilateral ventral intermediate thalamic nucleus (VIM) stimulation on sleep. DESIGN: Three consecutive full-night polysomnography recordings were made in the laboratory. After the habituation night, a random order for night ON-stim and OFF-stim was applied for the second and third nights. SETTING: Sleep disorders unit of a university hospital. PATIENTS: Eleven patients with bilateral stimulation of the ventral intermediate nucleus of the thalamus (VIM) for drug-resistant tremor. MEASUREMENTS: Sleep measures on polysomnography. RESULTS: Total sleep time was reduced during night ON-stim compared to OFF- stim, as well as rapid eye movement sleep percentage while the percentage of N2 increased. Wakefulness after sleep onset time was increased. CONCLUSION: Our results show that bilateral stimulation of the VIM nuclei reduces sleep and could be associated with insomnia.
STUDY OBJECTIVES: To explore the influence of acute bilateral ventral intermediate thalamic nucleus (VIM) stimulation on sleep. DESIGN: Three consecutive full-night polysomnography recordings were made in the laboratory. After the habituation night, a random order for night ON-stim and OFF-stim was applied for the second and third nights. SETTING:Sleep disorders unit of a university hospital. PATIENTS: Eleven patients with bilateral stimulation of the ventral intermediate nucleus of the thalamus (VIM) for drug-resistant tremor. MEASUREMENTS: Sleep measures on polysomnography. RESULTS: Total sleep time was reduced during night ON-stim compared to OFF- stim, as well as rapid eye movement sleep percentage while the percentage of N2 increased. Wakefulness after sleep onset time was increased. CONCLUSION: Our results show that bilateral stimulation of the VIM nuclei reduces sleep and could be associated with insomnia.
Authors: T Hori; Y Sugita; E Koga; S Shirakawa; K Inoue; S Uchida; H Kuwahara; M Kousaka; T Kobayashi; Y Tsuji; M Terashima; K Fukuda; N Fukuda Journal: Psychiatry Clin Neurosci Date: 2001-06 Impact factor: 5.188