| Literature DB >> 25514385 |
Karen Martins1, Christopher Cooper, Travis Warren, Jay Wells, Todd Bell, Jolynne Raymond, Kelly Stuthman, Jacqueline Benko, Nicole Garza, Sean van Tongeren, Ginger Donnelly, Cary Retterer, Lian Dong, Sina Bavari.
Abstract
The rhesus macaque serves as an animal model for Ebola virus (EBOV) infection. A thorough understanding of EBOV infection in this species would aid in further development of filovirus therapeutics and vaccines. In this study, pathological and immunological data from EBOV-infected rhesus macaques are presented. Changes in blood chemistries, hematology, coagulation, and immune parameters during infection, which were consistently observed in the animals, are presented. In an animal that survived challenge, a delay was observed in the detection of viral RNA and inflammatory cytokines and chemokines which may have contributed to survival. Collectively, these data add to the body of knowledge regarding EBOV pathogenesis in rhesus macaques and emphasize the reproducibility of the rhesus macaque challenge model.Entities:
Mesh：
Year: 2015 PMID： 25514385 DOI： 10.1089/vim.2014.0085
Source DB: PubMed Journal: Viral Immunol ISSN： 0882-8245 Impact factor: 2.257