Literature DB >> 25514180

Rewiring mitochondrial pyruvate metabolism: switching off the light in cancer cells?

Peter W Szlosarek1, SukJun Lee2, Patrick J Pollard3.   

Abstract

Metabolic reprogramming is a characteristic of cancer cells. Three studies published in this month's Molecular Cell provide novel insights into the role of mitochondrial pyruvate in tumor metabolism and describe how targeting pyruvate transport and metabolism may afford therapeutic benefit.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25514180     DOI： 10.1016/j.molcel.2014.10.018

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  7 in total

1.  Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.

Authors:  Cyril Corbet; Estelle Bastien; Nihed Draoui; Bastien Doix; Lionel Mignion; Bénédicte F Jordan; Arnaud Marchand; Jean-Christophe Vanherck; Patrick Chaltin; Olivier Schakman; Holger M Becker; Olivier Riant; Olivier Feron
Journal:  Nat Commun       Date:  2018-03-23       Impact factor: 14.919

Review 2.  Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism.

Authors:  Balaraman Kalyanaraman
Journal:  Redox Biol       Date:  2017-04-13       Impact factor: 11.799

3.  Genetic polymorphisms in the telomere length-related gene ACYP2 are associated with the risk of colorectal cancer in a Chinese Han population.

Authors:  Fang Liu; Zhongguo Zhang; Yong Zhang; Yue Chen; Xiaoyu Yang; Jibin Li; Jiaxing Zhao
Journal:  Oncotarget       Date:  2017-02-07

4.  Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males.

Authors:  Wenhui Zhao; Fanglin Niu; Zhilan Xie; Mengdan Yan; Jingjie Li; Yuan Zhang; Jun Chen; Qiufang Liu; Tianbo Jin
Journal:  Mol Genet Genomic Med       Date:  2019-05-29       Impact factor: 2.183

5.  A Holistic View of Berberine Inhibiting Intestinal Carcinogenesis in Conventional Mice Based on Microbiome-Metabolomics Analysis.

Authors:  Haitao Chen; Fan Zhang; Jin Zhang; Xinjie Zhang; Yong Guo; Qinghua Yao
Journal:  Front Immunol       Date:  2020-09-24       Impact factor: 7.561

6.  ING5 differentially regulates protein lysine acetylation and promotes p300 autoacetylation.

Authors:  Tao Zhang; Jin Meng; Xinli Liu; Xutao Zhang; Xiaojun Peng; Zhongyi Cheng; Feng Zhang
Journal:  Oncotarget       Date:  2017-10-31

7.  LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1.

Authors:  Stella Logotheti; Stephan Marquardt; Shailendra K Gupta; Christin Richter; Berdien A H Edelhäuser; David Engelmann; Julia Brenmoehl; Christoph Söhnchen; Nico Murr; Michael Alpers; Krishna P Singh; Olaf Wolkenhauer; Dirk Heckl; Alf Spitschak; Brigitte M Pützer
Journal:  Theranostics       Date:  2020-07-29       Impact factor: 11.556
  7 in total

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