Literature DB >> 25514044

C. elegans as a model to study PTEN's regulation and function.

Jun Liu1, Ian D Chin-Sang2.   

Abstract

PTEN (phosphatase and tensin homolog deleted on chromosome 10) has important roles in tumor suppression, metabolism, and development, yet its regulators, effectors, and functions are not fully understood. DAF-18 is the PTEN ortholog in Caenorhabditis elegans. DAF-18's role is highly conserved to human PTEN, and can be functionally replaced by human PTEN. Thus C. elegans provides a valuable model to study PTEN. This review assesses current and emerging methods to study DAF-18's regulators and functions in C. elegans. We propose genetic modify screens to identify genes that interact with daf-18/PTEN. These genes are potential targets for anticancer drug therapies. We also provide a review on the roles DAF-18/PTEN has during C. elegans development and how studying these physiological roles can provide mechanistic insight on DAF-18/PTEN function.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  C. elegans; DAF-18; Genetics; PTEN; Tumor suppressor

Mesh：

Substances：

Year:  2014        PMID： 25514044     DOI： 10.1016/j.ymeth.2014.12.009

Source DB:  PubMed          Journal:  Methods        ISSN： 1046-2023            Impact factor:   3.608


  7 in total

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