Chun-Hong Liu1, Xin Ma2, Lu-Ping Song3, Jin Fan4, Wei-Dong Wang5, Xue-Yu Lv5, Yu Zhang1, Feng Li1, Lihong Wang6, Chuan-Yue Wang1. 1. Beijing Key Laboratory of Mental Disorders, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China. 2. Beijing Key Laboratory of Mental Disorders, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China. Electronic address: maxinanding@vip.163.com. 3. Rehabilitation College of Capital Medical University, China Rehabilitation Research Center, Beijing 100068, China. 4. Department of Psychology, Queens College, The City University of New York, Queens, NY 11367, USA. 5. Department of Psychology, Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China. 6. Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 10084, China. Electronic address: lihong001@gmail.com.
Abstract
OBJECTIVE: Anxious depression is a distinct clinical subtype of major depressive disorder (MDD) characterized by palpitations, somatic complaints, altered interoceptive awareness, high risk of suicide, and poor response to pharmacotherapy. However, the neural mechanisms of anxious depression are still not well understood. In this study we investigated changes in neural oscillation during the resting-state of patients with anxious depression by measuring differences in the amplitude of low-frequency fluctuation (ALFF). METHODS: Resting-state functional magnetic resonance imaging was acquired in 31 patients with anxious depression, 18 patients with remitted depression, as well as 68 gender- and age-matched healthy participants. We compared the differences both in the ALFF and fractional ALFF (fALFF) among the three groups. We also examined the correlation between the ALFF/fALFF and the severity of anxiety as well as depression. RESULTS: Anxious depression patients showed increased ALFF/fALFF in the right dorsal anterior insular cortex and decreased ALFF/fALFF in the bilateral lingual gyrus relative to remitted depression patients and healthy controls. The increased ALFF in the dorsal anterior insula was also positively correlated with stronger anxiety in the anxious depression group. Anxious depression patients also displayed increased fALFF in the right ventral anterior cingulate cortex (ACC) compared to remitted depression patients and healthy controls. CONCLUSIONS: Our results suggest that alterations of the cortico-limbic networks, including the right dorsal anterior insula and right ventral ACC, may play a critical role in the physiopathology of anxious depression.
OBJECTIVE:Anxious depression is a distinct clinical subtype of major depressive disorder (MDD) characterized by palpitations, somatic complaints, altered interoceptive awareness, high risk of suicide, and poor response to pharmacotherapy. However, the neural mechanisms of anxious depression are still not well understood. In this study we investigated changes in neural oscillation during the resting-state of patients with anxious depression by measuring differences in the amplitude of low-frequency fluctuation (ALFF). METHODS: Resting-state functional magnetic resonance imaging was acquired in 31 patients with anxious depression, 18 patients with remitted depression, as well as 68 gender- and age-matched healthy participants. We compared the differences both in the ALFF and fractional ALFF (fALFF) among the three groups. We also examined the correlation between the ALFF/fALFF and the severity of anxiety as well as depression. RESULTS:Anxious depressionpatients showed increased ALFF/fALFF in the right dorsal anterior insular cortex and decreased ALFF/fALFF in the bilateral lingual gyrus relative to remitted depressionpatients and healthy controls. The increased ALFF in the dorsal anterior insula was also positively correlated with stronger anxiety in the anxious depression group. Anxious depressionpatients also displayed increased fALFF in the right ventral anterior cingulate cortex (ACC) compared to remitted depressionpatients and healthy controls. CONCLUSIONS: Our results suggest that alterations of the cortico-limbic networks, including the right dorsal anterior insula and right ventral ACC, may play a critical role in the physiopathology of anxious depression.
Authors: Lejla Colic; Meng Li; Liliana Ramona Demenescu; Shija Li; Iris Müller; Anni Richter; Gusalija Behnisch; Constanze I Seidenbecher; Oliver Speck; Björn H Schott; Oliver Stork; Martin Walter Journal: J Neurosci Date: 2018-05-03 Impact factor: 6.167
Authors: Julie Coloigner; Yeun Kim; Adam Bush; Soyoung Choi; Melissa C Balderrama; Thomas D Coates; Sharon H O'Neil; Natasha Lepore; John C Wood Journal: PLoS One Date: 2017-10-05 Impact factor: 3.240