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Literature DB >> 25512204

Investigating the anti-leishmanial effects of linear peptoids.

Gabriela A Eggimann¹, Hannah L Bolt, Paul W Denny, Steven L Cobb.

Abstract

Peptoids, a class of peptide mimetics, have emerged as promising anti-infective agents against a range of bacterial infections. Herein we present the first study of the antiparasitic and specifically the anti-leishmanial properties of linear peptoids. Peptoids were identified as having promising activity against Leishmania mexicana axenic amastigotes, a causative agent of cutaneous leishmaniasis.

Entities: Disease

Keywords: Leishmania; anti-leishmanial agents; antiparasitic agents; peptoids

Mesh：

Substances：

Year: 2014 PMID： 25512204 DOI： 10.1002/cmdc.201402416

Source DB: PubMed Journal: ChemMedChem ISSN： 1860-7179 Impact factor: 3.466

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Cited

12 in total

1. Fluorinated Aromatic Monomers as Building Blocks To Control α-Peptoid Conformation and Structure.

Authors: Diana Gimenez; Guangfeng Zhou; Matthew F D Hurley; Juan A Aguilar; Vincent A Voelz; Steven L Cobb
Journal: J Am Chem Soc Date: 2019-02-15 Impact factor: 15.419

Review 2. Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.

Authors: Natalia Molchanova; Paul R Hansen; Henrik Franzyk
Journal: Molecules Date: 2017-08-29 Impact factor: 4.411

3. Pep-Calc.com: a set of web utilities for the calculation of peptide and peptoid properties and automatic mass spectral peak assignment.

Authors: Sam Lear; Steven L Cobb
Journal: J Comput Aided Mol Des Date: 2016-02-24 Impact factor: 3.686

4. An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity.

Authors: Hannah L Bolt; Paul W Denny; Steven L Cobb
Journal: J Vis Exp Date: 2016-11-02 Impact factor: 1.355

5. Log D versus HPLC derived hydrophobicity: The development of predictive tools to aid in the rational design of bioactive peptoids.

Authors: H L Bolt; C E J Williams; R V Brooks; R N Zuckermann; S L Cobb; E H C Bromley
Journal: Biopolymers Date: 2017-07 Impact factor: 2.505

Investigating the anti-leishmanial effects of linear peptoids.

1. Fluorinated Aromatic Monomers as Building Blocks To Control α-Peptoid Conformation and Structure.

Review 2. Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.

3. Pep-Calc.com: a set of web utilities for the calculation of peptide and peptoid properties and automatic mass spectral peak assignment.

4. An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity.

5. Log D versus HPLC derived hydrophobicity: The development of predictive tools to aid in the rational design of bioactive peptoids.

6. Stabilising Peptoid Helices Using Non-Chiral Fluoroalkyl Monomers.

Review 7. Recent Advances in the Synthesis of Peptoid Macrocycles.

8. Synthesis of Antibacterial Nisin⁻Peptoid Hybrids Using Click Methodology.

9. Peptoid Efficacy against Polymicrobial Biofilms Determined by Using Propidium Monoazide-Modified Quantitative PCR.

10. Exploring the links between peptoid antibacterial activity and toxicity.