M De la Calle1, R Rodriguez, L Deirós, J L Bartha. 1. Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, University Hospital La Paz, Madrid, Spain.
Abstract
OBJECTIVE: Previous studies have suggested that antiretroviral therapy in human immunodeficiency virus (HIV)-infected pregnant women can cause alterations in cardiac structure and function in fetuses or children, although the results are not very clear. The aim of this study is to assess whether or not these alterations are present in the heart of fetuses of HIV-infected pregnant women, undergoing treatment with highly active antiretroviral therapy (HAART). STUDY DESIGN: We performed a prospective study on 29 consecutive HIV-positive pregnant women treated with HAART and 70 consecutive HIV-negative pregnant women as controls. Fetal cardiac biometry and function was evaluated by echocardiography at 30-32 weeks of gestation. Fetal biometry, estimated fetal weight and umbilical artery Doppler were also measured. RESULTS: We found E/A tricuspid ratio values slightly increased (0.84 vs 0.80, p = 0.03) and diastolic length shortened (49.7 vs 51.7%, p = 0.03) in the HIV-infected group. The rest of the biometric and functional cardiac parameters were not different between both groups. There were no cases of vertical transmission of HIV infection. CONCLUSION: In HIV-infected pregnant women treated with HAART, no significant changes are showed in fetal cardiac parameters.
OBJECTIVE: Previous studies have suggested that antiretroviral therapy in human immunodeficiency virus (HIV)-infected pregnant women can cause alterations in cardiac structure and function in fetuses or children, although the results are not very clear. The aim of this study is to assess whether or not these alterations are present in the heart of fetuses of HIV-infected pregnant women, undergoing treatment with highly active antiretroviral therapy (HAART). STUDY DESIGN: We performed a prospective study on 29 consecutive HIV-positive pregnant women treated with HAART and 70 consecutive HIV-negative pregnant women as controls. Fetal cardiac biometry and function was evaluated by echocardiography at 30-32 weeks of gestation. Fetal biometry, estimated fetal weight and umbilical artery Doppler were also measured. RESULTS: We found E/A tricuspid ratio values slightly increased (0.84 vs 0.80, p = 0.03) and diastolic length shortened (49.7 vs 51.7%, p = 0.03) in the HIV-infected group. The rest of the biometric and functional cardiac parameters were not different between both groups. There were no cases of vertical transmission of HIV infection. CONCLUSION: In HIV-infected pregnant women treated with HAART, no significant changes are showed in fetal cardiac parameters.
Authors: Laura García-Otero; Marta López; Mariona Guitart-Mampel; Constanza Morén; Anna Goncé; Carol Esteve; Laura Salazar; Olga Gómez; Josep María Martínez; Berta Torres; Sergi César; Glòria Garrabou; Fàtima Crispi; Eduard Gratacós Journal: PLoS One Date: 2019-03-04 Impact factor: 3.240
Authors: Alexandra Ursache; Alexandra Maria Tibeica; Alexandru Luca; Mircea Onofriescu; Daniela Roxana Matasariu; Dragos Nemescu Journal: Exp Ther Med Date: 2021-04-14 Impact factor: 2.447