Kyoung Sook Jeong1, Hyewon Park2, Eunhee Ha3, Yun-Chul Hong4, Mina Ha5, Hyesook Park3, Bung-Nyun Kim6, Bo-Eun Lee7, Soo-Jeong Lee8, Kyung Yeon Lee9, Ja Hyeong Kim9, Yangho Kim10. 1. Department of Occupational and Environmental Medicine, Dongguk University College of Medicine, Dongguk University Ilsan Hospital, Goyang, Republic of Korea. 2. Dept of Child and Family Welfare, University of Ulsan, Ulsan, Republic of Korea. 3. Department of Preventive Medicine, Ewha Medical Research Center, School of Medicine, Ewha Womans University, Seoul, Republic of Korea. 4. Institute of Environmental Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea. 5. Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan, Republic of Korea. 6. Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea. 7. Environmental Health Research Division, National Institute of Environmental Research, Incheon, Republic of Korea. 8. Department of Obstetrics and Gynecology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea. 9. Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea. 10. Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea. Electronic address: yanghokm@nuri.net.
Abstract
OBJECTIVE: To investigate whether performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy. METHOD: The present study is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project in Korea that began in 2006. The study cohort consisted of 119 children whose mothers underwent testing of blood cadmium during early pregnancy. All children were evaluated using the Korean version of the Wechsler Preschool and Primary Scale of Intelligence, revised edition (WPPSI-R), at 60 months of age. Multivariate linear regression analysis was performed to analyze the correlation between IQ in children and maternal blood cadmium concentration in early pregnancy, after adjustment for covariates. RESULTS: Maternal blood cadmium concentration during early pregnancy was inversely associated with performance IQ, after adjustment for covariates such as sex, educational levels of both parents, family income, and maternal BMI. Maternal blood cadmium concentration, however, was not associated with cognitive IQ. CONCLUSION: Performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy.
OBJECTIVE: To investigate whether performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy. METHOD: The present study is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project in Korea that began in 2006. The study cohort consisted of 119 children whose mothers underwent testing of blood cadmium during early pregnancy. All children were evaluated using the Korean version of the Wechsler Preschool and Primary Scale of Intelligence, revised edition (WPPSI-R), at 60 months of age. Multivariate linear regression analysis was performed to analyze the correlation between IQ in children and maternal blood cadmium concentration in early pregnancy, after adjustment for covariates. RESULTS: Maternal blood cadmium concentration during early pregnancy was inversely associated with performance IQ, after adjustment for covariates such as sex, educational levels of both parents, family income, and maternal BMI. Maternal blood cadmium concentration, however, was not associated with cognitive IQ. CONCLUSION: Performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy.
Authors: Weili Yang; Ann M Vuong; Changchun Xie; Kim N Dietrich; Margaret R Karagas; Bruce P Lanphear; Joseph M Braun; Kimberly Yolton; Aimin Chen Journal: Environ Res Date: 2020-04-25 Impact factor: 6.498
Authors: Gail A Wasserman; Xinhua Liu; Faruque Parvez; Yu Chen; Pam Factor-Litvak; Nancy J LoIacono; Diane Levy; Hasan Shahriar; Mohammed Nasir Uddin; Tariqul Islam; Angela Lomax; Roheeni Saxena; Elizabeth A Gibson; Marianthi-Anna Kioumourtzoglou; Olgica Balac; Tiffany Sanchez; Jennie K Kline; David Santiago; Tyler Ellis; Alexander van Geen; Joseph H Graziano Journal: Environ Int Date: 2018-06-20 Impact factor: 9.621
Authors: Pei Wen Tung; Amber Burt; Margaret Karagas; Brian P Jackson; Tracy Punshon; Barry Lester; Carmen J Marsit Journal: Environ Epidemiol Date: 2022-01-28