Literature DB >> 25511320

Evaluation of urinary miRNA-96 as a potential biomarker for bladder cancer diagnosis.

Sanaa Eissa1, Haidy Habib, Esraa Ali, Yossif Kotb.   

Abstract

For bladder cancer, a new diagnostic marker is needed to avoid painful cystoscopy. The aim of this study was to explore the efficacy of urinary miRNA-96 as molecular marker in bladder cancer diagnosis and its relation to bilharziasis. Urine cytology, serologic assessment of schistosomiasis and estimation of miRNA-96 by real-time PCR were carried out for 94 bladder cancer patients, 30 benign bladder lesions and 60 healthy individuals. Expression of miRNA-96 showed a significant difference among the three tested groups and also between benign and malignant bilharzial cases. Urinary miRNA-96 is a good noninvasive diagnostic biomarker for bladder cancer.

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Year:  2014        PMID： 25511320     DOI： 10.1007/s12032-014-0413-x

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  22 in total

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