Literature DB >> 2550855

Peculiarities of receptor-channel complexes for inhibitory mediators in the membranes of lamprey spinal cord neurones.

B V Safronov1, K V Baev, I V Batueva, K I Rusin, E I Suderevskaya.   

Abstract

Effects of inhibitory mediators on the membranes of isolated lamprey spinal cord neurones were investigated by means of whole-cell recording and concentration clamp techniques. Glycine and gamma-aminobutyric acid (GABA) applications evoked desensitizing chloride currents. The concentrations at half-maximum effects were 16 microM for glycine- and 1.5 mM for GABA-activated currents. Ionic responses to applications of both amino acids demonstrated full cross-desensitization. Strychnine and bicuculline suppressed both glycine- and GABA-activated conductances to the same degree. We suggest that in the membranes of lamprey spinal cord neurones glycine and GABA act on the same receptor-channel complexes.

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Year:  1989        PMID： 2550855     DOI： 10.1016/0304-3940(89)90311-x

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

1.  Interaction of the postsynaptic effects of glycine and GABA on spinal cord neurons in the frog Rana temporaria.

Authors:  E A Tsvetkov; N P Veselkin
Journal:  Neurosci Behav Physiol       Date:  2008-07-08

2.  Differences in the activation of inhibitory motoneuron receptors in the frog Rana ridibunda by GABA and glycine and their interaction.

Authors:  N I Kalinina; G G Kurchavyi; D V Amakhin; N P Veselkin
Journal:  Neurosci Behav Physiol       Date:  2009-09-23

3.  Colocalization of neurotransmitters in presynaptic boutons of inhibitory synapses in the lamprey spinal cord.

Authors:  N P Veselkin; V O Adanina; J P Rio; J Repérant
Journal:  Neurosci Behav Physiol       Date:  2000 Sep-Oct

4.  Sensitivity of spinal neurons to GABA and glycine during voluntary movement in behaving monkeys.

Authors:  Guoji Wu; Steve I Perlmutter
Journal:  J Neurophysiol       Date:  2012-10-17       Impact factor: 2.714

5.  Effects of strychnine on fictive swimming in the lamprey: evidence for glycinergic inhibition, discrepancies with model predictions, and novel modulatory rhythms.

Authors:  D R McPherson; J T Buchanan; S Kasicki
Journal:  J Comp Physiol A       Date:  1994-09       Impact factor: 1.836

6.  Cellular and synaptic modulation underlying substance P-mediated plasticity of the lamprey locomotor network.

Authors:  D Parker; S Grillner
Journal:  J Neurosci       Date:  1998-10-01       Impact factor: 6.167

7.  Inhibitory effect of strychnine on acetylcholine receptor activation in bovine adrenal medullary chromaffin cells.

Authors:  G A Kuijpers; L A Vergara; S Calvo; G Yadid
Journal:  Br J Pharmacol       Date:  1994-10       Impact factor: 8.739
  7 in total

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