Literature DB >> 2550828

Chemical integrity of [3H]GABA used in binding studies.

V J Balcar1.   

Abstract

A method which is claimed to be able to determine the proportion of "true" GABA within radiolabeled GABA used in binding studies was tested using [3H]GABA. The method was found to be unsuitable for 3H-labeled GABA and, furthermore, both theoretical considerations and the present experimental data indicated that it could also produce misleading results with [14C]GABA.

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Year:  1989        PMID： 2550828     DOI： 10.1007/BF00964866

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  10 in total

1.  Neurotransmitter uptake into slices of rat cerebral cortex in vitro: effect of slice size.

Authors:  D R Riddall; M J Leach; A N Davison
Journal:  J Neurochem       Date:  1976-10       Impact factor: 5.372

2.  A method for the determination of the integrity of labeled GABA used in membrane receptor binding assay.

Authors:  A Cupello; G Besio; P Mainardi
Journal:  Neurochem Res       Date:  1987-03       Impact factor: 3.996

3.  Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA receptor binding.

Authors:  A Schousboe; P Thorbek; L Hertz; P Krogsgaard-Larsen
Journal:  J Neurochem       Date:  1979-07       Impact factor: 5.372

4.  Amino-oxyacetic acid: a relatively non-specific inhibitor of uptake of amino acids and amines by brain and spinal cord.

Authors:  G A Johnston; V J Balcar
Journal:  J Neurochem       Date:  1974-04       Impact factor: 5.372

5.  Effects of amino-oxyacetic acid on ( 3 H)GABA uptake by rat brain slices.

Authors:  S R Snodgrass; L L Iversen
Journal:  J Neurochem       Date:  1973-02       Impact factor: 5.372

6.  GABA uptake in rat central nervous system: comparison of uptake in slices and homogenates and the effects of some inhibitors.

Authors:  L L Iversen; G A Johnston
Journal:  J Neurochem       Date:  1971-10       Impact factor: 5.372

7.  GABA receptor binding in rat cerebral cortex and superior cervical ganglion in the absence of GABAergic synapses.

Authors:  V J Balcar; F Joó; P Kása; I E Dammasch; J R Wolff
Journal:  Neurosci Lett       Date:  1986-05-23       Impact factor: 3.046

8.  Ontogeny of K(+)-stimulated release of [(3)H]GABA in rat cerebral cortex studied by a simple technique in vitro.

Authors:  V J Balcar; S Damm; J R Wolff
Journal:  Neurochem Int       Date:  1986       Impact factor: 3.921

9.  Presence of radiolabelled metabolites in release studies using [3H]gamma-aminobutyric acid.

Authors:  C R Gardner; M H Richards
Journal:  J Neurochem       Date:  1981-04       Impact factor: 5.372

10.  A high-affinity, Na+-dependent uptake system for gamma-hydroxybutyrate in membrane vesicles prepared from rat brain.

Authors:  J Benavides; J F Rumigny; J J Bourguignon; C G Wermuth; P Mandel; M Maitre
Journal:  J Neurochem       Date:  1982-06       Impact factor: 5.372
  10 in total

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