Literature DB >> 25506891

Twist-BRD4 complex: potential drug target for basal-like breast cancer.

Jian Shi, Jingying Cao, Binhua P Zhou1.   

Abstract

As an important basic helix-loop-helix (bHLH) transcription factor, Twist associates with several physiological processes such as mesodermal development, and pathological processes such as Saethre-Chotzen syndrome. During cancer progression, Twist induces epithelial-mesenchymal transition (EMT), potentiating cancer cell invasion and metastasis. Although many studies have revealed its multiple biological roles, it remained unclear how Twist transcriptionally activates targeted genes. Recently we discovered tip60-mediated Twist di-acetylation in the ''histone H4-mimic'' GK-X-GK motif. The di-acetylated Twist recruits BRD4 and related transcriptional components to super-enhancer of its targeted genes during progression of basal-like breast cancer (BLBC). Here, we review this new advance of regulation and functional mechanism of Twist.

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Year:  2015        PMID： 25506891      PMCID： PMC5644350          DOI： 10.2174/1381612821666141211153853

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  79 in total

1.  G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer.

Authors:  Chenfang Dong; Yadi Wu; Jun Yao; Yifan Wang; Yinhua Yu; Piotr G Rychahou; B Mark Evers; Binhua P Zhou
Journal:  J Clin Invest       Date:  2012-03-12       Impact factor: 14.808

2.  Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.

Authors:  Bo Huang; Xiao-Dong Yang; Ming-Ming Zhou; Keiko Ozato; Lin-Feng Chen
Journal:  Mol Cell Biol       Date:  2008-12-22       Impact factor: 4.272

3.  A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation.

Authors:  Sara Piccinin; Elena Tonin; Sara Sessa; Silvia Demontis; Sabrina Rossi; Lorenza Pecciarini; Lucia Zanatta; Flavia Pivetta; Alessandra Grizzo; Maura Sonego; Camillo Rosano; Angelo Paolo Dei Tos; Claudio Doglioni; Roberta Maestro
Journal:  Cancer Cell       Date:  2012-09-11       Impact factor: 31.743

4.  Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

Authors:  Sebastian Schröder; Sungyoo Cho; Lei Zeng; Qiang Zhang; Katrin Kaehlcke; Lily Mak; Joann Lau; Dwayne Bisgrove; Martina Schnölzer; Eric Verdin; Ming-Ming Zhou; Melanie Ott
Journal:  J Biol Chem       Date:  2011-11-14       Impact factor: 5.157

5.  Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression.

Authors:  Zhao-Qiu Wu; Xiao-Yan Li; Casey Yuexian Hu; Michael Ford; Celina G Kleer; Stephen J Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-24       Impact factor: 11.205

Review 6.  Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms.

Authors:  Qian Qin; Young Xu; Tao He; Chunlin Qin; Jianming Xu
Journal:  Cell Res       Date:  2011-08-30       Impact factor: 25.617

Review 7.  Management of breast cancer with targeted agents: importance of heterogeneity. [corrected].

Authors:  Serena Di Cosimo; José Baselga
Journal:  Nat Rev Clin Oncol       Date:  2010-02-02       Impact factor: 66.675

8.  Selective inhibition of tumor oncogenes by disruption of super-enhancers.

Authors:  Jakob Lovén; Heather A Hoke; Charles Y Lin; Ashley Lau; David A Orlando; Christopher R Vakoc; James E Bradner; Tong Ihn Lee; Richard A Young
Journal:  Cell       Date:  2013-04-11       Impact factor: 41.582

9.  Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.

Authors:  Gongda Xue; David F Restuccia; Qiang Lan; Debby Hynx; Stephan Dirnhofer; Daniel Hess; Curzio Rüegg; Brian A Hemmings
Journal:  Cancer Discov       Date:  2012-01-25       Impact factor: 39.397

10.  Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer.

Authors:  C Dong; Y Wu; Y Wang; C Wang; T Kang; P G Rychahou; Y-I Chi; B M Evers; B P Zhou
Journal:  Oncogene       Date:  2012-05-07       Impact factor: 9.867
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  15 in total

Review 1.  Autophagy regulation in the development and treatment of breast cancer.

Authors:  Yuting Zhou; Edmund B Rucker; Binhua P Zhou
Journal:  Acta Biochim Biophys Sin (Shanghai)       Date:  2015-12-05       Impact factor: 3.848

2.  Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

Authors:  William R Shadrick; Peter J Slavish; Sergio C Chai; Brett Waddell; Michele Connelly; Jonathan A Low; Cynthia Tallant; Brandon M Young; Nagakumar Bharatham; Stefan Knapp; Vincent A Boyd; Marie Morfouace; Martine F Roussel; Taosheng Chen; Richard E Lee; R Kiplin Guy; Anang A Shelat; Philip M Potter
Journal:  Bioorg Med Chem       Date:  2017-11-04       Impact factor: 3.641

3.  Genome-wide identification, classification, and functional analysis of the basic helix-loop-helix transcription factors in the cattle, Bos Taurus.

Authors:  Fengmei Li; Wuyi Liu
Journal:  Mamm Genome       Date:  2017-03-15       Impact factor: 2.957

Review 4.  BET proteins: Investigating BRDT as a potential target for male contraception.

Authors:  Andrea Wisniewski; Gunda I Georg
Journal:  Bioorg Med Chem Lett       Date:  2020-01-21       Impact factor: 2.823

5.  Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.

Authors:  Maria Delcuratolo; Jasmin Fertey; Markus Schneider; Johanna Schuetz; Natalie Leiprecht; Benjamin Hudjetz; Stephan Brodbeck; Silke Corall; Marcel Dreer; Roxana Michaela Schwab; Martin Grimm; Shwu-Yuan Wu; Frank Stubenrauch; Cheng-Ming Chiang; Thomas Iftner
Journal:  PLoS Pathog       Date:  2016-01-04       Impact factor: 6.823

6.  BRD4 inhibition suppresses cell growth, migration and invasion of salivary adenoid cystic carcinoma.

Authors:  Limei Wang; Xiuyin Wu; Ruolin Wang; Chengzhe Yang; Zhi Li; Cunwei Wang; Fenghe Zhang; Pishan Yang
Journal:  Biol Res       Date:  2017-05-25       Impact factor: 5.612

7.  Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers.

Authors:  Chuan-Huizi Chen; Nong Yang; Yongchang Zhang; Jiancheng Ding; Wenjuan Zhang; Rong Liu; Wen Liu; Ceshi Chen
Journal:  Int J Biol Sci       Date:  2019-06-10       Impact factor: 6.580

8.  HIF-1α, TWIST-1 and ITGB-1, associated with Tumor Stiffness, as Novel Predictive Markers for the Pathological Response to Neoadjuvant Chemotherapy in Breast Cancer.

Authors:  Jing Zhang; Shuo Zhang; Song Gao; Yan Ma; Xueying Tan; Ye Kang; Weidong Ren
Journal:  Cancer Manag Res       Date:  2020-03-24       Impact factor: 3.989

9.  The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains.

Authors:  Artyom A Alekseyenko; Erica M Walsh; Xin Wang; Adlai R Grayson; Peter T Hsi; Peter V Kharchenko; Mitzi I Kuroda; Christopher A French
Journal:  Genes Dev       Date:  2015-07-15       Impact factor: 11.361

10.  Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma.

Authors:  Shumei Song; Yuan Li; Yan Xu; Lang Ma; Melissa Pool Pizzi; Jiankang Jin; Ailing W Scott; Longfei Huo; Ying Wang; Jeffrey H Lee; Manoop S Bhutani; Brian Weston; Namita D Shanbhag; Randy L Johnson; Jaffer A Ajani
Journal:  Mol Oncol       Date:  2020-04-07       Impact factor: 6.603
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