Janice K Kiecolt-Glaser1, Lisa Jaremka2, Rebecca Andridge3, Juan Peng3, Diane Habash4, Christopher P Fagundes5, Ronald Glaser6, William B Malarkey7, Martha A Belury8. 1. Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus, OH 43210, USA; Department of Psychiatry, The Ohio State University Medical Center, Columbus, OH 43210, USA. Electronic address: Janice.Kiecolt-Glaser@osumc.edu. 2. Department of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, USA. 3. Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH 43210, USA. 4. Health and Rehabilitation Sciences, The Ohio State University Medical Center, Columbus, OH 43210, USA. 5. Department of Health Disparities Research, MD Anderson Cancer Center, Houston, TX 77030, USA. 6. Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus, OH 43210, USA. 7. Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus, OH 43210, USA; Department of Psychiatry, The Ohio State University Medical Center, Columbus, OH 43210, USA; Department of Medicine, The Ohio State University Medical Center, Columbus, OH 43210, USA. 8. Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA.
Abstract
BACKGROUND: Longitudinal studies have implicated both marital distress and depression in the development of the metabolic syndrome, a risk factor for diabetes and cardiovascular disease. This study addressed the impact of hostile marital interactions and a mood disorder history on obesity-related metabolic responses to high-fat meals. METHODS: This double-blind, randomized crossover study included serial assessments of resting energy expenditure (REE), fat and carbohydrate oxidation, triglycerides, insulin, glucose, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) before and after two high-fat meals. During two separate 9.5h visits, 43 healthy married couples, ages 24-61 (mean=38.22), received either a high saturated fat meal or a high oleic sunflower oil meal, both 930kcal and 60g fat. The Structured Diagnostic Interview for DSM-IV assessed mood disorder history. Couples discussed a marital disagreement during both visits; behavioral coding of these interactions provided data on hostile marital behaviors. RESULTS: Men and women who displayed more hostile behaviors and who also had a mood disorder history had significantly lower post-meal REE, higher insulin, and higher peak triglyceride responses than other participants, with nonsignificant effects for fat and carbohydrate oxidation. Participants with a mood disorder history had a steeper rise in postprandial IL-6 and glucose than those without a past history. Higher levels of hostile behaviors were associated with higher post-meal TNF-α. The two meals did not differ on any outcome assessed. CONCLUSIONS: People spend about 18 of every 24h in a postprandial state, and dining with one's partner is a common daily event. Among subjects with a mood disorder history, the cumulative 6.75-h difference between high and low hostile behaviors translates into 128kcal, a difference that could add 7.6pounds/year. Our findings illustrate novel pathways through which chronic marital stress and a mood disorder history synergistically heighten the risk for obesity, metabolic syndrome, and cardiovascular disease.
RCT Entities:
BACKGROUND: Longitudinal studies have implicated both marital distress and depression in the development of the metabolic syndrome, a risk factor for diabetes and cardiovascular disease. This study addressed the impact of hostile marital interactions and a mood disorder history on obesity-related metabolic responses to high-fat meals. METHODS: This double-blind, randomized crossover study included serial assessments of resting energy expenditure (REE), fat and carbohydrate oxidation, triglycerides, insulin, glucose, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) before and after two high-fat meals. During two separate 9.5h visits, 43 healthy married couples, ages 24-61 (mean=38.22), received either a high saturated fat meal or a high oleicsunflower oil meal, both 930kcal and 60g fat. The Structured Diagnostic Interview for DSM-IV assessed mood disorder history. Couples discussed a marital disagreement during both visits; behavioral coding of these interactions provided data on hostile marital behaviors. RESULTS:Men and women who displayed more hostile behaviors and who also had a mood disorder history had significantly lower post-meal REE, higher insulin, and higher peak triglyceride responses than other participants, with nonsignificant effects for fat and carbohydrate oxidation. Participants with a mood disorder history had a steeper rise in postprandial IL-6 and glucose than those without a past history. Higher levels of hostile behaviors were associated with higher post-meal TNF-α. The two meals did not differ on any outcome assessed. CONCLUSIONS:People spend about 18 of every 24h in a postprandial state, and dining with one's partner is a common daily event. Among subjects with a mood disorder history, the cumulative 6.75-h difference between high and low hostile behaviors translates into 128kcal, a difference that could add 7.6pounds/year. Our findings illustrate novel pathways through which chronic marital stress and a mood disorder history synergistically heighten the risk for obesity, metabolic syndrome, and cardiovascular disease.
Authors: Janice K Kiecolt-Glaser; Timothy J Loving; Jeffrey R Stowell; William B Malarkey; Stanley Lemeshow; Stephanie L Dickinson; Ronald Glaser Journal: Arch Gen Psychiatry Date: 2005-12
Authors: Y Milaneschi; S Bandinelli; B W Penninx; N Vogelzangs; A M Corsi; F Lauretani; A Kisialiou; R Vazzana; A Terracciano; J M Guralnik; L Ferrucci Journal: Mol Psychiatry Date: 2010-11-02 Impact factor: 15.992
Authors: Ellen E Blaak; Gabby Hul; Camilla Verdich; Vladimir Stich; Alfredo Martinez; Martin Petersen; Edith F M Feskens; Kishor Patel; Jean Michel Oppert; Pierre Barbe; Søren Toubro; Ingalena Anderson; Jan Polak; Arne Astrup; Ian A Macdonald; Dominique Langin; Claus Holst; Thorkild I Sørensen; Wim H M Saris Journal: J Clin Endocrinol Metab Date: 2006-01-31 Impact factor: 5.958
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Authors: Janice K Kiecolt-Glaser; Kristopher J Preacher; Robert C MacCallum; Cathie Atkinson; William B Malarkey; Ronald Glaser Journal: Proc Natl Acad Sci U S A Date: 2003-07-02 Impact factor: 11.205
Authors: Heather M Derry; Avelina C Padin; Jennifer L Kuo; Spenser Hughes; Janice K Kiecolt-Glaser Journal: Curr Psychiatry Rep Date: 2015-10 Impact factor: 5.285
Authors: Stephanie J Wilson; Lisa M Jaremka; Christopher P Fagundes; Rebecca Andridge; Juan Peng; William B Malarkey; Diane Habash; Martha A Belury; Janice K Kiecolt-Glaser Journal: Psychoneuroendocrinology Date: 2017-02-16 Impact factor: 4.905
Authors: Stephanie J Wilson; Brittney E Bailey; Lisa M Jaremka; Christopher P Fagundes; Rebecca Andridge; William B Malarkey; Kathleen M Gates; Janice K Kiecolt-Glaser Journal: Psychoneuroendocrinology Date: 2018-04-21 Impact factor: 4.905
Authors: Diana A Chirinos; Luz M Garcini; Annina Seiler; Kyle W Murdock; Kristen Peek; Raymond P Stowe; Christopher Fagundes Journal: Ann Behav Med Date: 2019-08-16
Authors: Martha A Belury; Rachel M Cole; Brittney E Bailey; Jia-Yu Ke; Rebecca R Andridge; Janice K Kiecolt-Glaser Journal: Mol Nutr Food Res Date: 2016-03-22 Impact factor: 5.914
Authors: Janice K Kiecolt-Glaser; Stephanie J Wilson; Michael L Bailey; Rebecca Andridge; Juan Peng; Lisa M Jaremka; Christopher P Fagundes; William B Malarkey; Bryon Laskowski; Martha A Belury Journal: Psychoneuroendocrinology Date: 2018-08-04 Impact factor: 4.905
Authors: Luz M Garcini; Diana A Chirinos; Kyle W Murdock; Annina Seiler; Angie S LeRoy; Kristen Peek; Malcom P Cutchin; Christopher Fagundes Journal: J Behav Med Date: 2017-12-21