Literature DB >> 25506415

Histological evaluation of a biomimetic material in bone regeneration after one year from graft.

Michele M Figliuzzi1, Rossella De Fazio1, Rosamaria Tiano1, Serena De Franceschi1, Delfina Pacifico1, Francesco Mangano2, Leonzio Fortunato1.   

Abstract

AIM: The use of substitute materials is one of the solutions used in periodontology for the reconstruction of intrabony defects. Advances in scientific research gave rise to a new generation of biomaterials of synthetic origin stoichiometrically unstable and therefore really absorbable. Our research is directed precisely towards a biomaterial synthesis, Engipore® (Finceramica, Faenza, Italy) which is a bone substitute of the latest hydroxyapatite-based generation, that possesses chemical and morphological properties similar to those of natural bone in the treatment of infrabony periodontal defects. Aim of this study was to evaluate the efficacy of Engipore® in the treatment of intrabony periodontal defects.
METHODS: The study was conducted on 100 parodontopatics patients, which had gingival pockets of at least infrabonies 8/10 mm. The histological evaluation was performed with samples after one year from the graft.
RESULTS: The histological samples collected after one year showed an abundant new bone formation, with mature lamellar bone tissue surrounding the residual particles of Engipore® that appear completely osteointegrated. The surrounding connective tissue shows no signs of inflammation.
CONCLUSIONS: The results obtained in our research demonstrated that, after a proper selection of patients and lesions, and applying an adequate surgical technique, this type of biomaterial in the treatment of periodontal defects acts in an optimal manner as a filler inducing the formation of new bone as evidenced by histological examinations.

Entities:  

Keywords:  biomimetic material; bone regeneration; intrabony defects; periosteum

Year:  2014        PMID: 25506415      PMCID: PMC4252859     

Source DB:  PubMed          Journal:  Ann Stomatol (Roma)        ISSN: 1824-0852


  19 in total

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Journal:  Arthritis Rheum       Date:  2002-12

Review 2.  Stem cells and periodontal regeneration.

Authors:  P Mark Bartold; Songtao Shi; Stan Gronthos
Journal:  Periodontol 2000       Date:  2006       Impact factor: 7.589

3.  Effects of a putty-form hydroxyapatite matrix combined with the synthetic cell-binding peptide P-15 on alveolar ridge preservation.

Authors:  Rodrigo F Neiva; Yi-Pin Tsao; Robert Eber; Jeffrey Shotwell; Edward Billy; Hom-Lay Wang
Journal:  J Periodontol       Date:  2008-02       Impact factor: 6.993

4.  The morphogenesis of bone in replicas of porous hydroxyapatite obtained from conversion of calcium carbonate exoskeletons of coral.

Authors:  U Ripamonti
Journal:  J Bone Joint Surg Am       Date:  1991-06       Impact factor: 5.284

5.  Clinical performance of a regenerative strategy for intrabony defects: scientific evidence and clinical experience.

Authors:  Pierpaolo Cortellini; Maurizio S Tonetti
Journal:  J Periodontol       Date:  2005-03       Impact factor: 6.993

6.  Clinical and radiographic outcomes of the modified minimally invasive surgical technique with and without regenerative materials: a randomized-controlled trial in intra-bony defects.

Authors:  Pierpaolo Cortellini; Maurizio S Tonetti
Journal:  J Clin Periodontol       Date:  2011-02-08       Impact factor: 8.728

7.  Magnesium-enriched hydroxyapatite compared to calcium sulfate in the healing of human extraction sockets: radiographic and histomorphometric evaluation at 3 months.

Authors:  Roberto Crespi; Paolo Capparè; Enrico Gherlone
Journal:  J Periodontol       Date:  2009-02       Impact factor: 6.993

Review 8.  Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review.

Authors:  Kevin G Murphy; John C Gunsolley
Journal:  Ann Periodontol       Date:  2003-12

9.  Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/beta TCP in periodontal osseous defects.

Authors:  E B Nery; R Z LeGeros; K L Lynch; K Lee
Journal:  J Periodontol       Date:  1992-09       Impact factor: 6.993

10.  Engipore acts on human bone marrow stem cells.

Authors:  Vincenzo Sollazzo; Annalisa Palmieri; Ambra Girardi; Francesca Farinella; Francesco Carinci
Journal:  Saudi Dent J       Date:  2010-07-17
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  2 in total

1.  Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis.

Authors:  Michele Mario Figliuzzi; Amerigo Giudice; Settimia Pileggi; Francesco Scordamaglia; Massimo Marrelli; Marco Tatullo; Leonzio Fortunato
Journal:  Ann Stomatol (Roma)       Date:  2016-07-19

2.  Bone-like ceramic scaffolds designed with bioinspired porosity induce a different stem cell response.

Authors:  Silvia Panseri; Monica Montesi; Dominique Hautcoeur; Samuele M Dozio; Shaan Chamary; Eamonn De Barra; Anna Tampieri; Anne Leriche
Journal:  J Mater Sci Mater Med       Date:  2021-01-20       Impact factor: 3.896

  2 in total

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