Literature DB >> 25505249

The unexpected evolution of basic science studies about cyclic nucleotide action into a treatment for erectile dysfunction.

Jackie Corbin1.   

Abstract

In these Reflections, I describe my perceived role in discoveries made in the cyclic nucleotide field that culminated in the advent of PDE5 inhibitors that treat erectile dysfunction, such as Viagra, Levitra, and Cialis. The discoveries emphasize the critical role of basic science, which often evolves in unpredictable and circuitous paths, in improving human health.
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  Cyclic AMP (cAMP); Cyclic GMP (cGMP); Phosphodiesterases; Protein Kinase A (PKA); Protein Kinase G (PKG)

Mesh：

Substances：

Year:  2014        PMID： 25505249      PMCID： PMC4340384          DOI： 10.1074/jbc.X114.632174

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  41 in total

1.  Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues.

Authors:  S Katsuki; W P Arnold; F Murad
Journal:  J Cyclic Nucleotide Res       Date:  1977-08

2.  Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens.

Authors:  K Schultz; K Schultz; G Schultz
Journal:  Nature       Date:  1977-02-24       Impact factor: 49.962

3.  Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3':5'-monophosphate-dependent protein kinase.

Authors:  J D Corbin; P H Sugden; L West; D A Flockhart; T M Lincoln; D McCarthy
Journal:  J Biol Chem       Date:  1978-06-10       Impact factor: 5.157

4.  Characterization of a novel cGMP binding protein from rat lung.

Authors:  S H Francis; T M Lincoln; J D Corbin
Journal:  J Biol Chem       Date:  1980-01-25       Impact factor: 5.157

5.  Vascular mechanisms involved in erection and erectile disorders.

Authors:  G Wagner
Journal:  Clin Endocrinol Metab       Date:  1982-11

6.  Effects of nitroprusside, glyceryl trinitrate, and 8-bromo cyclic GMP on phosphorylase a formation and myosin light chain phosphorylation in rat aorta.

Authors:  R M Johnson; T M Lincoln
Journal:  Mol Pharmacol       Date:  1985-03       Impact factor: 4.436

7.  Compartmentalization of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in heart tissue.

Authors:  J D Corbin; P H Sugden; T M Lincoln; S L Keely
Journal:  J Biol Chem       Date:  1977-06-10       Impact factor: 5.157

8.  Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase.

Authors:  S H Francis; B D Noblett; B W Todd; J N Wells; J D Corbin
Journal:  Mol Pharmacol       Date:  1988-10       Impact factor: 4.436

9.  Adenosine 3':5'-cyclic monophosphate- and guanosine 3':5'-cyclic monophosphate-dependent protein kinases: possible homologous proteins.

Authors:  T M Lincoln; J D Corbin
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

10.  Studies of two different intrachain cGMP-binding sites of cGMP-dependent protein kinase.

Authors:  J D Corbin; S O Døskeland
Journal:  J Biol Chem       Date:  1983-09-25       Impact factor: 5.157
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