Literature DB >> 25505049

Cryptococcal meningoencephalitis relapse after an eight-year delay: an interplay of infection and immune reconstitution.

Juri Katchanov1, Cristiane Blechschmidt2, Kirsten Nielsen3, Gordian Branding4, Keikawus Arastéh5, Kathrin Tintelnot6, Graeme Meintjes7, David R Boulware8, Hartmut Stocker5.   

Abstract

We report a case of a symptomatic relapse of HIV-related cryptococcal meningoencephalitis eight years after the first diagnosis on the background of immune reconstitution. The findings as well as the clinical course suggests a combination of smouldering localised infection and enhanced inflammatory reaction related to immune restoration due to antiretroviral therapy. A combination of antifungal and anti-inflammatory therapy resulted in clinical and radiological improvement. Our case challenges the concept that immune reconstitution inflammatory syndrome and microbiological relapse are dichotomous entities.
© The Author(s) 2015.

Entities:  

Keywords:  AIDS; CNS cryptococcosis; Cryptococcus neoformans; HIV; IRIS; antiretroviral therapy; cryptococcal meningitis; immune restoration; opportunistic infection

Mesh：

Substances：

Year:  2014        PMID： 25505049      PMCID： PMC4779056          DOI： 10.1177/0956462414563630

Source DB:  PubMed          Journal:  Int J STD AIDS        ISSN： 0956-4624            Impact factor:   1.359


  3 in total

1.  Diagnosis and Management of Cryptococcal Relapse.

Authors:  Abdu K Musubire; David R Boulware; David B Meya; Joshua Rhein
Journal:  J AIDS Clin Res       Date:  2013-04-29

2.  Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study.

Authors:  David R Boulware; David B Meya; Tracy L Bergemann; Darin L Wiesner; Joshua Rhein; Abdu Musubire; Sarah J Lee; Andrew Kambugu; Edward N Janoff; Paul R Bohjanen
Journal:  PLoS Med       Date:  2010-12-21       Impact factor: 11.069

3.  Cryptococcal immune reconstitution inflammatory syndrome in HIV-1-infected individuals: proposed clinical case definitions.

Authors:  Lewis J Haddow; Robert Colebunders; Graeme Meintjes; Stephen D Lawn; Julian H Elliott; Yukari C Manabe; Paul R Bohjanen; Somnuek Sungkanuparph; Philippa J Easterbrook; Martyn A French; David R Boulware
Journal:  Lancet Infect Dis       Date:  2010-11       Impact factor: 25.071
  3 in total
  9 in total

1.  Cryptococcal Meningitis: Diagnosis and Management Update.

Authors:  Mahsa Abassi; David R Boulware; Joshua Rhein
Journal:  Curr Trop Med Rep       Date:  2015-06-01

Review 2.  HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment.

Authors:  Lauren N Bowen; Bryan Smith; Daniel Reich; Martha Quezado; Avindra Nath
Journal:  Nat Rev Neurol       Date:  2016-10-27       Impact factor: 42.937

Review 3.  Recent advances in AIDS-related cryptococcal meningitis treatment with an emphasis on resource limited settings.

Authors:  Sarah Lofgren; Mahsa Abassi; Joshua Rhein; David R Boulware
Journal:  Expert Rev Anti Infect Ther       Date:  2017-02-09       Impact factor: 5.091

4.  Case Report: A Case of Severe Cryptococcal Immune Reconstitution Inflammatory Syndrome Presenting with Brain and Intradural Abscesses in an HIV Patient.

Authors:  Thomas Kalinoski; Jason Malenfant; Catherine Yim; Arthur Jeng
Journal:  Am J Trop Med Hyg       Date:  2020-04-23       Impact factor: 2.345

5.  Gastrointestinal cryptococcoma - Immune reconstitution inflammatory syndrome or cryptococcal relapse in a patient with AIDS?

Authors:  Abdu K Musubire; David B Meya; Robert Lukande; Andrew Kambugu; Paul R Bohjanen; David R Boulware
Journal:  Med Mycol Case Rep       Date:  2015-03-26

6.  Neurosyphilis with Concomitant Cryptococcal and Tuberculous Meningitis in a Patient with AIDS: Report of a Unique Case.

Authors:  Jose Armando Gonzales Zamora; Luis Alberto Espinoza; Rita N Nwanyanwu
Journal:  Case Rep Infect Dis       Date:  2017-08-27

Review 7.  Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults.

Authors:  Caleb Skipper; Mahsa Abassi; David R Boulware
Journal:  J Fungi (Basel)       Date:  2019-07-19

8.  Early Antiretroviral Therapy in AIDS Patients Presenting With Toxoplasma gondii Encephalitis Is Associated With More Sequelae but Not Increased Mortality.

Authors:  Nadia Cubas-Vega; Paola López Del-Tejo; Djane C Baia-da-Silva; Vanderson Souza Sampaio; Bruno Araújo Jardim; Monique Freire Santana; Luiz Carlos Lima Ferreira; Izabella Picinin Safe; Márcia A Araújo Alexandre; Marcus Vinícius Guimarães Lacerda; Wuelton Marcelo Monteiro; Fernando Val
Journal:  Front Med (Lausanne)       Date:  2022-02-25

9.  A Retrospective Cohort Study of Lesion Distribution of HIV-1 Infection Patients With Cryptococcal Meningoencephalitis on MRI: Correlation With Immunity and Immune Reconstitution.

Authors:  Shuang Xia; Xueqin Li; Yanbin Shi; Jinxin Liu; Mengjie Zhang; Tenghui Gu; Shinong Pan; Liucun Song; Jinsheng Xu; Yan Sun; Qingxia Zhao; Zhiyan Lu; Puxuan Lu; Hongjun Li
Journal:  Medicine (Baltimore)       Date:  2016-02       Impact factor: 1.817
  9 in total

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