Literature DB >> 25504778

Reactions of difunctional electrophiles with functionalized aryllithium compounds: remarkable chemoselectivity by flash chemistry.

Aiichiro Nagaki1, Keita Imai, Satoshi Ishiuchi, Jun-ichi Yoshida.   

Abstract

Flash chemistry using flow microreactors enables highly chemoselective reactions of difunctional electrophiles with functionalized aryllithium compounds by virtue of extremely fast micromixing. The approach serves as a powerful method for protecting-group-free synthesis using organolithium compounds and opens a new possibility in the synthesis of polyfunctional organic molecules.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  chemoselectivity; flash chemistry; flow chemistry; microreactors; organolithium compounds

Year:  2014        PMID： 25504778     DOI： 10.1002/anie.201410717

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  4 in total

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