Literature DB >> 25504512

The roles of AXIN2 in tumorigenesis and epigenetic regulation.

Shuang Li1, Chunpeng Wang, Xiaodong Liu, Shucheng Hua, Xin Liu.   

Abstract

AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the development of liver cancer, colon cancer, lung cancer, breast cancer and so on. The epigenetic regulation provides new insights for further exploring the pathogenesis of tumor. In this paper, the roles of AXIN2 in tumorigenesis, AXIN2 methylation, ubiquitination and siRNA/RNA regulation will be reviewed.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 25504512     DOI： 10.1007/s10689-014-9775-7

Source DB:  PubMed          Journal:  Fam Cancer        ISSN： 1389-9600            Impact factor:   2.375


  60 in total

1.  Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling.

Authors:  W Liu; X Dong; M Mai; R S Seelan; K Taniguchi; K K Krishnadath; K C Halling; J M Cunningham; L A Boardman; C Qian; E Christensen; S S Schmidt; P C Roche; D I Smith; S N Thibodeau
Journal:  Nat Genet       Date:  2000-10       Impact factor: 38.330

Review 2.  DNA methylation and human disease.

Authors:  Keith D Robertson
Journal:  Nat Rev Genet       Date:  2005-08       Impact factor: 53.242

3.  New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites.

Authors:  Inhan Lee; Subramanian S Ajay; Jong In Yook; Hyun Sil Kim; Su Hyung Hong; Nam Hee Kim; Saravana M Dhanasekaran; Arul M Chinnaiyan; Brian D Athey
Journal:  Genome Res       Date:  2009-03-31       Impact factor: 9.043

4.  Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway.

Authors:  Eek-hoon Jho; Tong Zhang; Claire Domon; Choun-Ki Joo; Jean-Noel Freund; Frank Costantini
Journal:  Mol Cell Biol       Date:  2002-02       Impact factor: 4.272

5.  A new bioinformatics analysis tools framework at EMBL-EBI.

Authors:  Mickael Goujon; Hamish McWilliam; Weizhong Li; Franck Valentin; Silvano Squizzato; Juri Paern; Rodrigo Lopez
Journal:  Nucleic Acids Res       Date:  2010-05-03       Impact factor: 16.971

Review 6.  Gene regulation by methylation.

Authors:  Wolf C Mueller; Andreas von Deimling
Journal:  Recent Results Cancer Res       Date:  2009

7.  Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia.

Authors:  Maria E Figueroa; Shann-Ching Chen; Anna K Andersson; Letha A Phillips; Yushan Li; Jason Sotzen; Mondira Kundu; James R Downing; Ari Melnick; Charles G Mullighan
Journal:  J Clin Invest       Date:  2013-06-10       Impact factor: 14.808

8.  Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability.

Authors:  Min Sung Kim; Sung Soo Kim; Chang Hyeok Ahn; Nam Jin Yoo; Sug Hyung Lee
Journal:  Hum Pathol       Date:  2008-08-27       Impact factor: 3.466

9.  The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer.

Authors:  Yan Ni Loh; Ellen L Hedditch; Laura A Baker; Eve Jary; Robyn L Ward; Caroline E Ford
Journal:  BMC Cancer       Date:  2013-04-02       Impact factor: 4.430

10.  starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data.

Authors:  Jun-Hao Li; Shun Liu; Hui Zhou; Liang-Hu Qu; Jian-Hua Yang
Journal:  Nucleic Acids Res       Date:  2013-12-01       Impact factor: 16.971
View more
  9 in total

Review 1.  Wnt signaling: a double-edged sword in protecting bone from cancer.

Authors:  Xun Sun; Kexin Li; Bai-Yan Li; Hiroki Yokota
Journal:  J Bone Miner Metab       Date:  2022-08-30       Impact factor: 2.976

2.  Concurrent Hypermethylation of SFRP2 and DKK2 Activates the Wnt/β-Catenin Pathway and Is Associated with Poor Prognosis in Patients with Gastric Cancer.

Authors:  Hao Wang; Xiang-Long Duan; Xiao-Li Qi; Lei Meng; Yi-Song Xu; Tong Wu; Peng-Gao Dai
Journal:  Mol Cells       Date:  2017-01-26       Impact factor: 5.034

3.  Clinical relevance of breast and gastric cancer-associated polymorphisms as potential susceptibility markers for oral clefts in the Brazilian population.

Authors:  Renato Assis Machado; Edimilson Martins de Freitas; Sibele Nascimento de Aquino; Daniella Reis B Martelli; Mário Sérgio Oliveira Swerts; Silvia Regina de Almeida Reis; Darlene Camati Persuhn; Helenara Salvati Bertolossi Moreira; Verônica Oliveira Dias; Ricardo D Coletta; Hercílio Martelli-Júnior
Journal:  BMC Med Genet       Date:  2017-04-04       Impact factor: 2.103

4.  C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling.

Authors:  Jun Jiang; Shulin Tang; Jianhong Xia; Jikai Wen; Shuang Chen; Xiaodong Shu; Michael S Y Huen; Yiqun Deng
Journal:  Oncogene       Date:  2018-03-13       Impact factor: 9.867

5.  SMYD2 targets RIPK1 and restricts TNF-induced apoptosis and necroptosis to support colon tumor growth.

Authors:  Yu-Qiang Yu; Veronika Thonn; Jay V Patankar; Oana-Maria Thoma; Maximilian Waldner; Marta Zielinska; Li-Li Bao; Miguel Gonzalez-Acera; Stefan Wallmüller; Felix B Engel; Michael Stürzl; Markus F Neurath; Eva Liebing; Christoph Becker
Journal:  Cell Death Dis       Date:  2022-01-12       Impact factor: 8.469

6.  A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation.

Authors:  Gerard Llimos; Vincent Gardeux; Ute Koch; Judith F Kribelbauer; Antonina Hafner; Daniel Alpern; Joern Pezoldt; Maria Litovchenko; Julie Russeil; Riccardo Dainese; Riccardo Moia; Abdurraouf Mokhtar Mahmoud; Davide Rossi; Gianluca Gaidano; Christoph Plass; Pavlo Lutsik; Clarissa Gerhauser; Sebastian M Waszak; Alistair Boettiger; Freddy Radtke; Bart Deplancke
Journal:  Nat Commun       Date:  2022-04-19       Impact factor: 17.694

7.  SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer.

Authors:  Huidi Liu; Emilio Mastriani; Zi-Qiao Yan; Si-Yuan Yin; Zheng Zeng; Hong Wang; Qing-Hai Li; Hong-Yu Liu; Xiaoyu Wang; Hong-Xia Bao; Yu-Jie Zhou; Jun-Jie Kou; Dongsheng Li; Ting Li; Jianrui Liu; Yongfang Liu; Lin Yin; Li Qiu; Liling Gong; Shu-Lin Liu
Journal:  Sci Rep       Date:  2016-05-18       Impact factor: 4.379

Review 8.  Molecular regulation and pharmacological targeting of the β-catenin destruction complex.

Authors:  Eline C van Kappel; Madelon M Maurice
Journal:  Br J Pharmacol       Date:  2017-08-11       Impact factor: 8.739

9.  Multilevel regulation of Wnt signaling by Zic2 in colon cancer due to mutation of β-catenin.

Authors:  Zhengshui Xu; Jianbao Zheng; Zilu Chen; Jing Guo; Xiaopeng Li; Xingjie Wang; Chao Qu; Liyue Yuan; Chen Cheng; Xuejun Sun; Junhui Yu
Journal:  Cell Death Dis       Date:  2021-06-07       Impact factor: 8.469
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.