PURPOSE: No safe ultrasound (US) parameters have been established to differentiate the causes of graft dysfunction. OBJECTIVES: To define US parameters and identify the predictors of normal graft evolution, delayed graft function (DGF), and rejection at the early period after kidney transplantation. METHODS: Between June 2012 and August 2013, 79 renal transplant recipients underwent US examination 1-3 days posttransplantation. Resistive index (RI), power Doppler (PD), and RI + PD (quantified PD) were assessed. Patients were allocated into three groups: normal graft evolution, DGF, and rejection. RESULTS: Resistive index of upper and middle segments and PD were higher in the DGF group than in the normal group. ROC curve analysis revealed that RI + PD was the index that best correlated with DGF (cutoff = 0.84). In the high RI + PD group, time to renal function recovery (6.33 ± 6.5 days) and number of dialysis sessions (2.81 ± 2.8) were greater than in the low RI + PD group (2.11 ± 5.3 days and 0.69 ± 1.5 sessions, respectively), p = 0.0001. Multivariate analysis showed that high donor final creatinine with a relative risk (RR) of 19.7 (2.01-184.7, p = 0.009) and older donor age (RR = 1.17 (1.04-1.32), p = 0.007) correlated with risk DGF. CONCLUSIONS: Quantified PD (RI + PD) was the best DGF predictor. PD quantification has not been previously reported.
PURPOSE: No safe ultrasound (US) parameters have been established to differentiate the causes of graft dysfunction. OBJECTIVES: To define US parameters and identify the predictors of normal graft evolution, delayed graft function (DGF), and rejection at the early period after kidney transplantation. METHODS: Between June 2012 and August 2013, 79 renal transplant recipients underwent US examination 1-3 days posttransplantation. Resistive index (RI), power Doppler (PD), and RI + PD (quantified PD) were assessed. Patients were allocated into three groups: normal graft evolution, DGF, and rejection. RESULTS: Resistive index of upper and middle segments and PD were higher in the DGF group than in the normal group. ROC curve analysis revealed that RI + PD was the index that best correlated with DGF (cutoff = 0.84). In the high RI + PD group, time to renal function recovery (6.33 ± 6.5 days) and number of dialysis sessions (2.81 ± 2.8) were greater than in the low RI + PD group (2.11 ± 5.3 days and 0.69 ± 1.5 sessions, respectively), p = 0.0001. Multivariate analysis showed that high donor final creatinine with a relative risk (RR) of 19.7 (2.01-184.7, p = 0.009) and older donor age (RR = 1.17 (1.04-1.32), p = 0.007) correlated with risk DGF. CONCLUSIONS: Quantified PD (RI + PD) was the best DGF predictor. PD quantification has not been previously reported.
Authors: O H Koning; R J Ploeg; J H van Bockel; M Groenewegen; F J van der Woude; G G Persijn; J Hermans Journal: Transplantation Date: 1997-06-15 Impact factor: 4.939
Authors: M Pascual; H Vallhonrat; A B Cosimi; N Tolkoff-Rubin; R B Colvin; F L Delmonico; D S Ko; D A Schoenfeld; W W Williams Journal: Transplantation Date: 1999-03-15 Impact factor: 4.939
Authors: Haytham M Shebel; Ahmed Akl; Ahmed Dawood; Tarek A El-Diasty; Ahmed A Shokeir; Mohamed A Ghoneim Journal: Saudi J Kidney Dis Transpl Date: 2014-07
Authors: E Lechevallier; B Dussol; A Luccioni; X Thirion; H Vacher-Copomat; K Jaber; P Brunet; F Leonetti; O Lavelle; C Coulange; Y Berland Journal: Am J Kidney Dis Date: 1998-12 Impact factor: 8.860
Authors: Giorgia Comai; Olga Baraldi; Vania Cuna; Valeria Corradetti; Andrea Angeletti; Seidju Brunilda; Irene Capelli; Maria Cappuccilli; Gaetano LA Manna Journal: In Vivo Date: 2018 Mar-Apr Impact factor: 2.155