Hiroyuki Namba1, Ryo Kawasaki2, Mari Narumi1, Akira Sugano1, Kei Homma3, Katsuhiro Nishi1, Takanori Murakami1, Takeo Kato4, Takamasa Kayama5, Hidetoshi Yamashita1. 1. Department of Ophthalmology and Visual Science, Yamagata University Faculty of Medicine, Yamagata City, Yamagata, Japan. 2. Department of Public Health, Yamagata University Faculty of Medicine, Yamagata City, Yamagata, Japan. 3. Okitama Public General Hospital, Kawanishi-machi, Yamagata, Japan. 4. Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata City, Yamagata, Japan. 5. Department of Neurosurgery, Yamagata University Faculty of Medicine, Yamagata City, Yamagata, Japan.
Abstract
PURPOSE: To investigate the relationship between age and ocular higher-order wavefront aberrations (HOAs) in an adult Japanese population, in addition to factors associated with HOA variations. METHODS: In the Yamagata Study (Funagata) cohort, 227 adult Japanese participants (aged 37-86 years) underwent systemic and ophthalmologic examinations in 2012. Ocular, corneal, and internal HOAs were measured in micrometers. From the Zernike coefficients, we calculated the root mean square of the total HOA, coma, and spherical aberration for a pupil diameter of 4 mm. Linear regression analyses were used to determine whether HOAs were associated with age or other factors. RESULTS: Multiple adjusted linear regression analyses demonstrated that all components of logarithmic HOAs increase with age. Ocular, corneal, and internal HOAs increased by 0.012/y (P < 0.001), 0.007/y (P = 0.010), and 0.014/y (P < 0.001), respectively. Ocular coma also significantly increased with age (0.010/y, P = 0.007), but corneal (P = 0.963) and internal (P = 0.476) coma did not. Age-related spherical aberration increased only in the internal component (0.019/y, P = 0.001). In addition to age, ocular and corneal HOAs were mainly affected by corneal indexes. CONCLUSIONS: Aging is associated with increases in ocular HOAs, independent of other possible confounding factors. The association of ocular HOAs with corneal parameters indicates that ocular HOAs are mainly generated by the cornea. Internal HOAs, supposedly generated from cataract progression, may be associated with systemic factors, including serum creatinine levels and blood pressure. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
PURPOSE: To investigate the relationship between age and ocular higher-order wavefront aberrations (HOAs) in an adult Japanese population, in addition to factors associated with HOA variations. METHODS: In the Yamagata Study (Funagata) cohort, 227 adult Japanese participants (aged 37-86 years) underwent systemic and ophthalmologic examinations in 2012. Ocular, corneal, and internal HOAs were measured in micrometers. From the Zernike coefficients, we calculated the root mean square of the total HOA, coma, and spherical aberration for a pupil diameter of 4 mm. Linear regression analyses were used to determine whether HOAs were associated with age or other factors. RESULTS: Multiple adjusted linear regression analyses demonstrated that all components of logarithmic HOAs increase with age. Ocular, corneal, and internal HOAs increased by 0.012/y (P < 0.001), 0.007/y (P = 0.010), and 0.014/y (P < 0.001), respectively. Ocular coma also significantly increased with age (0.010/y, P = 0.007), but corneal (P = 0.963) and internal (P = 0.476) coma did not. Age-related spherical aberration increased only in the internal component (0.019/y, P = 0.001). In addition to age, ocular and corneal HOAs were mainly affected by corneal indexes. CONCLUSIONS: Aging is associated with increases in ocular HOAs, independent of other possible confounding factors. The association of ocular HOAs with corneal parameters indicates that ocular HOAs are mainly generated by the cornea. Internal HOAs, supposedly generated from cataract progression, may be associated with systemic factors, including serum creatinine levels and blood pressure. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
Authors: Santiago Delgado-Tirado; Alberto López-Miguel; Yazmin Báez-Peralta; Lucía González-Buendía; Itziar Fernández; Jorge L Alió; Miguel J Maldonado; Rosa M Coco-Martín Journal: BMC Ophthalmol Date: 2021-05-18 Impact factor: 2.209