Francesco Cavallin1, Marco Scarpa2, Rita Alfieri2, Matteo Cagol2, Alberto Ruol3, Massimo Rugge4, Ermanno Ancona2, Carlo Castoro2. 1. Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy cescocava@libero.it. 2. Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy. 3. Department of Surgical Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy. 4. Department of Diagnostic Medical Sciences and Special Therapies, University of Padua, Padua, Italy.
Abstract
BACKGROUND: Esophageal carcinosarcoma (ESC) is a rare malignant lesion of the esophagus with controversial characteristics and prognostic factors. PATIENTS AND METHODS: Seventeen consecutive patients with esophageal carcinosarcoma were referred to the Center for Esophageal Diseases located in Padua from January 1, 1980 to December 31, 2011. Clinical characteristics, pathological features, treatment and outcome were retrospectively analyzed in a prospectively collected database. RESULTS: Five patients received palliative treatment and one refused surgery; they died of unresected tumor or progression of disease within 0.6-43.5 months after diagnosis. Eleven patients underwent surgical treatment with complete tumor resection; recurrence rate was 80%, leading to death within 2 years after surgery. Only two resected patients are currently alive and free of disease over 20 years after surgery. CONCLUSION: Our results did not support the better prognosis concept of esophageal carcinosarcoma and suggested the importance of radical esophagectomy with adequate lymph node dissection. Copyright
BACKGROUND:Esophageal carcinosarcoma (ESC) is a rare malignant lesion of the esophagus with controversial characteristics and prognostic factors. PATIENTS AND METHODS: Seventeen consecutive patients with esophageal carcinosarcoma were referred to the Center for Esophageal Diseases located in Padua from January 1, 1980 to December 31, 2011. Clinical characteristics, pathological features, treatment and outcome were retrospectively analyzed in a prospectively collected database. RESULTS: Five patients received palliative treatment and one refused surgery; they died of unresected tumor or progression of disease within 0.6-43.5 months after diagnosis. Eleven patients underwent surgical treatment with complete tumor resection; recurrence rate was 80%, leading to death within 2 years after surgery. Only two resected patients are currently alive and free of disease over 20 years after surgery. CONCLUSION: Our results did not support the better prognosis concept of esophageal carcinosarcoma and suggested the importance of radical esophagectomy with adequate lymph node dissection. Copyright
Authors: Xiaoyang Xu; Yan Xu; Jiang Wang; Can Zhao; Chang Liu; Bin Wu; Lei Gao; Guangquan Dai; Dongqiu Dai Journal: Medicine (Baltimore) Date: 2019-03 Impact factor: 1.817