BACKGROUND: Deep brain stimulation (DBS) of the globus pallidus internus is established as efficacious for dystonia, yet the optimal target within this structure is not well defined. Published evidence suggests that spatial normalization provides a better estimate of DBS lead location than traditional methods based on standard stereotactic coordinates. METHODS: We retrospectively reviewed our pallidal implanted dystonia population. Patient imaging scans were morphed into an MRI atlas using a nonlinear image registration algorithm. Active contact locations were projected onto the atlas and clusters analyzed for the degree of variance in two groups: (1) good and poor responders and (2) cervical (CD) and generalized dystonia (GD). RESULTS: The average active contact location between CD and GD good responders was distinct but not significantly different. The mean active contact for CD poor responders was significantly different from CD responders and GD poor responders in the dorsoventral direction. CONCLUSIONS: A normalized imaging space is arguably more accurate in visualizing postoperative leads. Despite some separation between groups, this data suggests there was not an optimal pallidal target for common dystonia patients. Degrees of variance overlapped due to a large degree of individual target variation. Patient selection may ultimately be the key to maximizing patient outcomes.
BACKGROUND: Deep brain stimulation (DBS) of the globus pallidus internus is established as efficacious for dystonia, yet the optimal target within this structure is not well defined. Published evidence suggests that spatial normalization provides a better estimate of DBS lead location than traditional methods based on standard stereotactic coordinates. METHODS: We retrospectively reviewed our pallidal implanted dystonia population. Patient imaging scans were morphed into an MRI atlas using a nonlinear image registration algorithm. Active contact locations were projected onto the atlas and clusters analyzed for the degree of variance in two groups: (1) good and poor responders and (2) cervical (CD) and generalized dystonia (GD). RESULTS: The average active contact location between CD and GD good responders was distinct but not significantly different. The mean active contact for CD poor responders was significantly different from CD responders and GD poor responders in the dorsoventral direction. CONCLUSIONS: A normalized imaging space is arguably more accurate in visualizing postoperative leads. Despite some separation between groups, this data suggests there was not an optimal pallidal target for common dystoniapatients. Degrees of variance overlapped due to a large degree of individual target variation. Patient selection may ultimately be the key to maximizing patient outcomes.
Authors: Peter E Konrad; Joseph S Neimat; Hong Yu; Chris C Kao; Michael S Remple; Pierre-François D'Haese; Benoit M Dawant Journal: Stereotact Funct Neurosurg Date: 2010-12-15 Impact factor: 1.875
Authors: Deanna J Greene; Scott Marek; Evan M Gordon; Joshua S Siegel; Caterina Gratton; Timothy O Laumann; Adrian W Gilmore; Jeffrey J Berg; Annie L Nguyen; Donna Dierker; Andrew N Van; Mario Ortega; Dillan J Newbold; Jacqueline M Hampton; Ashley N Nielsen; Kathleen B McDermott; Jarod L Roland; Scott A Norris; Steven M Nelson; Abraham Z Snyder; Bradley L Schlaggar; Steven E Petersen; Nico U F Dosenbach Journal: Neuron Date: 2019-12-10 Impact factor: 17.173
Authors: Caterina Gratton; Brian T Kraus; Deanna J Greene; Evan M Gordon; Timothy O Laumann; Steven M Nelson; Nico U F Dosenbach; Steven E Petersen Journal: Biol Psychiatry Date: 2019-11-07 Impact factor: 13.382