Literature DB >> 25501615

Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.

Lisa Rahangdale1, Kristina De Paris, Angela D M Kashuba, Julie A E Nelson, Mackenzie Cottrell, Craig Sykes, Cindi Emerson, Steven L Young, Trenton Stevens, Kristine B Patterson, Myron S Cohen.   

Abstract

: A comparative analysis of cellular and soluble markers of immune activation in HIV-infected women on combination antiretroviral therapy showed that the upper genital tract (UGT) compared to the lower female genital tract was characterized by higher frequencies of potential HIV target cells and increased inflammatory molecules. Despite the activated UGT milieu, HIV RNA could not be detected in paired samples of plasma, cervicovaginal or endometrial lavage. As antiretroviral concentrations were ≥3-fold higher in the endometrium than in the lower genital tract, high antiretroviral penetration and/or metabolism may limit viral replication in the UGT.

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Year:  2015        PMID： 25501615      PMCID： PMC4334681          DOI： 10.1097/QAI.0000000000000480

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN： 1525-4135            Impact factor:   3.731


  50 in total

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Authors:  D Hornung; I P Ryan; V A Chao; J L Vigne; E D Schriock; R N Taylor
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2.  Human immunodeficiency virus receptor and coreceptor expression on human uterine epithelial cells: regulation of expression during the menstrual cycle and implications for human immunodeficiency virus infection.

Authors:  Grant R Yeaman; Alexandra L Howell; Sally Weldon; Douglas J Demian; Jane E Collins; Denise M O'Connell; Susana N Asin; Charles R Wira; Michael W Fanger
Journal:  Immunology       Date:  2003-05       Impact factor: 7.397

3.  HIV-associated endometritis.

Authors:  M Peuchmaur; D Emilie; R Vazeux; J C Pons; J F Delfraissy; G Lemaigre; P Galanaud
Journal:  AIDS       Date:  1989-04       Impact factor: 4.177

4.  Chemokine receptor expression in human endometrium.

Authors:  Naciye Mulayim; Steven F Palter; Umit A Kayisli; Levent Senturk; Aydin Arici
Journal:  Biol Reprod       Date:  2002-11-27       Impact factor: 4.285

5.  Human immunodeficiency virus type 1 infection of human uterine epithelial cells: viral shedding and cell contact-mediated infectivity.

Authors:  Susana N Asin; Dunja Wildt-Perinic; Sarah I Mason; Alexandra L Howell; Charles R Wira; Michael W Fanger
Journal:  J Infect Dis       Date:  2003-04-23       Impact factor: 5.226

6.  Comparative prediction of perinatal human immunodeficiency virus type 1 transmission, using multiple virus load markers.

Authors:  Monty Montano; Matthew Russell; Peter Gilbert; Ibou Thior; Shahin Lockman; Roger Shapiro; Su-Yuan Chang; Tun Hou Lee; Max Essex
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7.  Immunohistochemical characterization of endometrial lymphoid cell populations in women infected with human immunodeficiency virus.

Authors:  F D Johnstone; A R Williams; G A Bird; S Bjornsson
Journal:  Obstet Gynecol       Date:  1994-04       Impact factor: 7.661

8.  Correlates of HIV-1 shedding in cervicovaginal secretions and effects of antiretroviral therapies.

Authors:  Josè Ramòn Fiore; Barbara Suligoi; Annalisa Saracino; Mariantonietta Di Stefano; Roberto Bugarini; Achiropita Lepera; Anna Favia; Laura Monno; Gioacchino Angarano; Giuseppe Pastore
Journal:  AIDS       Date:  2003-10-17       Impact factor: 4.177

9.  Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue.

Authors:  Qinxue Hu; Ines Frank; Vennansha Williams; John J Santos; Patricia Watts; George E Griffin; John P Moore; Melissa Pope; Robin J Shattock
Journal:  J Exp Med       Date:  2004-04-12       Impact factor: 14.307

10.  Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques.

Authors:  A I Spira; P A Marx; B K Patterson; J Mahoney; R A Koup; S M Wolinsky; D D Ho
Journal:  J Exp Med       Date:  1996-01-01       Impact factor: 14.307
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  4 in total

Review 1.  Pharmacology of Antiretrovirals in the Female Genital Tract for HIV Prevention.

Authors:  Melanie R Nicol; Joseph A Corbino; Mackenzie L Cottrell
Journal:  J Clin Pharmacol       Date:  2018-06-14       Impact factor: 3.126

2.  Intracellular Tenofovir and Emtricitabine Concentrations in Younger and Older Women with HIV Receiving Tenofovir Disoproxil Fumarate/Emtricitabine.

Authors:  Julie B Dumond; Camden P Bay; Julie A E Nelson; Angel Davalos; Andrew Edmonds; Kristina De Paris; Craig Sykes; Kathryn Anastos; Roopali Sharma; Seble Kassaye; Bani Tamraz; Audrey L French; Stephen Gange; Ighovwerha Ofotokun; Margaret A Fischl; David E Vance; Adaora A Adimora
Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191

3.  Female genital tract shedding of HIV-1 is rare in women with suppressed HIV-1 in plasma.

Authors:  Julie A E Nelson; Kristina De Paris; Catalina Ramirez; Andrew Edmonds; Katie R Mollan; Camden P Bay; Kara Compliment; Betsy C Herold; Kathryn Anastos; Howard Minkoff; Seble Kassaye; Dominika L Seidman; Audrey L French; Elizabeth T Golub; Anandi N Sheth; Christina Ochsenbauer; Ronald Swanstrom; Joseph J Eron; Adaora A Adimora
Journal:  AIDS       Date:  2020-01-01       Impact factor: 4.632

4.  Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells.

Authors:  Zheng Shen; Marta Rodriguez-Garcia; Mickey V Patel; Jack Bodwell; Angela D M Kashuba; Charles R Wira
Journal:  Sci Rep       Date:  2017-12-18       Impact factor: 4.379
  4 in total

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