| Literature DB >> 25501488 |
Mthulisi Khuphe1, Algy Kazlauciunas, Martin Huscroft, Paul D Thornton.
Abstract
The direct grafting of amphiphilic macromolecules by sequential n-carboxyanhydride ring-opening polymerisation (NCA ROP) from a therapeutic initiator enables the formation of monodisperse drug-containing micelles. The subsequent enzyme-mediated hydrolysis of the peptide component permits the programmed release of the encapsulated drug molecules, demonstrating a controlled drug delivery platform that negates any challenging payload loading procedures.Entities:
Mesh：
Substances：
Year: 2015 PMID： 25501488 DOI： 10.1039/c4cc08387c
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222