Literature DB >> 2550110

Subtypes of K+ channels differentiated by the effect of K+ channel openers upon K+ channel blocker-induced seizures.

G Gandolfo1, C Gottesmann, J N Bidard, M Lazdunski.   

Abstract

Intracerebroventricular injection of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), 3 blockers of a subclass of K+ channel, produces seizures and convulsions. Three different K+ channel openers are potent blockers of MCD-induced hyperexicitatory effects when they are administered preventively but they are unable to inhibit the epileptogenic effects induced by DTXI and 4-AP which were thought to block the same K+ channel which is blocked by MCD.

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Year:  1989        PMID： 2550110     DOI： 10.1016/0006-8993(89)91236-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  11 in total

1.  Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning.

Authors:  K P Giese; J F Storm; D Reuter; N B Fedorov; L R Shao; T Leicher; O Pongs; A J Silva
Journal:  Learn Mem       Date:  1998 Sep-Oct       Impact factor: 2.460

2.  Hormone-regulated K+ channels in follicle-enclosed oocytes are activated by vasorelaxing K+ channel openers and blocked by antidiabetic sulfonylureas.

Authors:  E Honoré; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-15       Impact factor: 11.205

3.  Actions of cromakalim on outward currents of CA1 neurones in hippocampal slices.

Authors:  G Erdemli; K Krnjević
Journal:  Br J Pharmacol       Date:  1994-10       Impact factor: 8.739

4.  K+ channel openers activate brain sulfonylurea-sensitive K+ channels and block neurosecretion.

Authors:  H Schmid-Antomarchi; S Amoroso; M Fosset; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

Review 5.  Molecular targets for antiepileptic drug development.

Authors:  Brian S Meldrum; Michael A Rogawski
Journal:  Neurotherapeutics       Date:  2007-01       Impact factor: 7.620

6.  Alterations of A-type potassium channels in hippocampal neurons after traumatic brain injury.

Authors:  Zhigang Lei; Ping Deng; Jinqing Li; Zao C Xu
Journal:  J Neurotrauma       Date:  2011-11-04       Impact factor: 5.269

7.  Cation-dependent uptake of zinc in human fibroblasts.

Authors:  M L Ackland; H J McArdle
Journal:  Biometals       Date:  1996-01       Impact factor: 2.949

Review 8.  Potassium Channels in Epilepsy.

Authors:  Rüdiger Köhling; Jakob Wolfart
Journal:  Cold Spring Harb Perspect Med       Date:  2016-05-02       Impact factor: 6.915

9.  TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo.

Authors:  Luis E Gonzalez-Reyes; Thomas P Ladas; Chia-Chu Chiang; Dominique M Durand
Journal:  Exp Neurol       Date:  2013-10-18       Impact factor: 5.330

10.  Sustained K(+) Outward Currents are Sensitive to Intracellular Heteropodatoxin2 in CA1 Neurons of Organotypic Cultured Hippocampi of Rats.

Authors:  Sung-Cherl Jung; Su-Yong Eun
Journal:  Korean J Physiol Pharmacol       Date:  2012-10-18       Impact factor: 2.016
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