Literature DB >> 2550109

Different GTP-binding proteins mediate regulation of calcium channels by acetylcholine and noradrenaline in rat sympathetic neurons.

S Y Song1, K Saito, K Noguchi, S Konishi.   

Abstract

In dissociated neurons of rat superior cervical ganglion (SCG), noradrenaline (NA) and acetylcholine (ACh) suppressed Ca2+ currents elicited by depolarizations to 0 mV from -60 mV. With GTP-gamma-S in patch electrodes, ACh and NA caused persistent inhibition of Ca2+ currents. Pretreatment of SCG cells with pertussis toxin abolished the action of ACh but not of NA. The results suggest that ACh and NA reduce the Ca2+ currents in SCG cells through different G proteins.

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Year:  1989        PMID： 2550109     DOI： 10.1016/0006-8993(89)90609-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  5 in total

1.  Pertussis toxin abolishes the inhibition of Ca2+ currents and of noradrenaline release via alpha 2-adrenoceptors in chick sympathetic neurons.

Authors:  S Boehm; S Huck; H Drobny; E A Singer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-05       Impact factor: 3.000

2.  Modulation of calcium currents via alpha 2-adrenoceptors in embryonic chick sympathetic neurons.

Authors:  S Boehm; S Huck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-09       Impact factor: 3.000

3.  Involvement of pertussis toxin-sensitive and -insensitive mechanisms in alpha-adrenoceptor modulation of noradrenaline release from rat sympathetic neurones in tissue culture.

Authors:  C E Hill; D A Powis; I A Hendry
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

4.  Pharmacology of the putative M4 muscarinic receptor mediating Ca-current inhibition in neuroblastoma x glioma hybrid (NG 108-15) cells.

Authors:  M P Caulfield; D A Brown
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739

5.  Adrenergic and cholinergic inhibition of Ca2+ channels mediated by different GTP-binding proteins in rat sympathetic neurones.

Authors:  S Y Song; K Saito; K Noguchi; S Konishi
Journal:  Pflugers Arch       Date:  1991-07       Impact factor: 3.657
  5 in total

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