Literature DB >> 25500871

The use of marine-derived bioactive compounds as potential hepatoprotective agents.

Dileep G Nair1, Ralf Weiskirchen2, Salma K Al-Musharafi1.   

Abstract

The marine environment may be explored as a rich source for novel drugs. A number of marine-derived compounds have been isolated and identified, and their therapeutic effects and pharmacological profiles are characterized. In the present review, we highlight the recent studies using marine compounds as potential hepatoprotective agents for the treatment of liver fibrotic diseases and discuss the proposed mechanisms of their activities. In addition, we discuss the significance of similar studies in Oman, where the rich marine life provides a potential for the isolation of novel natural, bioactive products that display therapeutic effects on liver diseases.

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Year:  2014        PMID： 25500871      PMCID： PMC4326787          DOI： 10.1038/aps.2014.114

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN： 1671-4083            Impact factor:   6.150


  81 in total

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Authors:  M Takei; D L Burgoyne; R J Andersen
Journal:  J Pharm Sci       Date:  1994-09       Impact factor: 3.534

3.  Protective effects of chitosan oligosaccharide and its derivatives against carbon tetrachloride-induced liver damage in mice.

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Journal:  Hepatol Res       Date:  2006-05-26       Impact factor: 4.288

4.  A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture.

Authors:  T Niki; K Rombouts; P De Bleser; K De Smet; V Rogiers; D Schuppan; M Yoshida; G Gabbiani; A Geerts
Journal:  Hepatology       Date:  1999-03       Impact factor: 17.425

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Journal:  Br J Pharmacol       Date:  2003-04       Impact factor: 8.739

Review 6.  Mechanism targeted discovery of antitumor marine natural products.

Authors:  Dale G Nagle; Yu-Dong Zhou; Flor D Mora; Kaleem A Mohammed; Yong-Pil Kim
Journal:  Curr Med Chem       Date:  2004-07       Impact factor: 4.530

7.  Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways.

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Journal:  Innate Immun       Date:  2013-01-22       Impact factor: 2.680

8.  Antioxidant and cytotoxic properties of two sea cucumbers, Holothuria edulis lesson and Stichopus horrens Selenka.

Authors:  O Y Althunibat; B H Ridzwan; M Taher; J M Daud; S Jauhari Arief Ichwan; H Qaralleh
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Authors:  Scott L Friedman; Dean Sheppard; Jeremy S Duffield; Shelia Violette
Journal:  Sci Transl Med       Date:  2013-01-09       Impact factor: 17.956

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Authors:  A M Gressner; R Weiskirchen
Journal:  J Cell Mol Med       Date:  2006 Jan-Mar       Impact factor: 5.310
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  9 in total

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Authors:  Sameh S Elhady; Marwa S Goda; Eman T Mehanna; Mahmoud A Elfaky; Abdulrahman E Koshak; Ahmad O Noor; Hanin A Bogari; Rania T Malatani; Reda F A Abdelhameed; Alaa S Wahba
Journal:  Biomedicines       Date:  2022-05-18

Review 3.  Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step.

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Journal:  Front Pharmacol       Date:  2016-01-07       Impact factor: 5.810

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Journal:  Mar Drugs       Date:  2015-04-03       Impact factor: 5.118

5.  The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling.

Authors:  Liang-Mou Kuo; Po-Jen Chen; Ping-Jyun Sung; Yu-Chia Chang; Chun-Ting Ho; Yi-Hsiu Wu; Tsong-Long Hwang
Journal:  Mar Drugs       Date:  2018-01-09       Impact factor: 5.118

6.  A Sargassum fluitans Borgesen Ethanol Extract Exhibits a Hepatoprotective Effect In Vivo in Acute and Chronic Liver Damage Models.

Authors:  Carlos Quintal-Novelo; Jorge Rangel-Méndez; Ángel Ortiz-Tello; Manlio Graniel-Sabido; Rebeca Pérez-Cabeza de Vaca; Rosa Moo-Puc
Journal:  Biomed Res Int       Date:  2018-12-20       Impact factor: 3.411

7.  The Marine Natural Product Manzamine A Inhibits Cervical Cancer by Targeting the SIX1 Protein.

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Review 8.  Natural Sulfur-Containing Compounds: An Alternative Therapeutic Strategy against Liver Fibrosis.

Authors:  Alfonsina Milito; Mariarita Brancaccio; Giuseppe D'Argenio; Immacolata Castellano
Journal:  Cells       Date:  2019-10-30       Impact factor: 6.600

9.  Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models.

Authors:  Adrian S Siregar; Marie Merci Nyiramana; Eun-Jin Kim; Eui-Jung Shin; Min Seok Woo; Jin-Mok Kim; Jung Hwan Kim; Dong Kun Lee; Jong Ryeal Hahm; Hyun Joon Kim; Chang-Woon Kim; Nam-Gil Kim; Si-Hyang Park; Yeung Joon Choi; Sang Soo Kang; Seong-Geun Hong; Jaehee Han; Dawon Kang
Journal:  Mar Drugs       Date:  2020-10-11       Impact factor: 5.118
  9 in total

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