Literature DB >> 25500239

Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease.

Robert S Rosenson1, Michael H Davidson2, Benjamin J Hirsh3, Sekar Kathiresan4, Daniel Gaudet5.   

Abstract

Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma triglycerides as a means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis and metabolism. We advocate that only a subset of genetic mechanisms regulating TGRLs contribute to the risk of CVD events. This "omic" approach recently resulted in new targets for reducing CVD events.
Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  atherosclerosis; cardiovascular disease; genetics; triglyceride; triglyceride-rich lipoproteins

Mesh：

Substances：

Year:  2014        PMID： 25500239     DOI： 10.1016/j.jacc.2014.09.042

Source DB:  PubMed          Journal:  J Am Coll Cardiol        ISSN： 0735-1097            Impact factor:   24.094


  73 in total

1.  Inhibition of perilipin 2 expression reduces pro-inflammatory gene expression and increases lipid droplet size.

Authors:  Jennifer E Norman; Hnin H Aung; Dennis W Wilson; John C Rutledge
Journal:  Food Funct       Date:  2018-12-13       Impact factor: 5.396

2.  Prevalence of metabolic syndrome and its components in women with and without pelvic organ prolapse and its association with prolapse severity according to the Pelvic Organ Prolapse Quantification system.

Authors:  Giulia Gava; Stefania Alvisi; Ilaria Mancini; Renato Seracchioli; Maria Cristina Meriggiola
Journal:  Int Urogynecol J       Date:  2018-12-12       Impact factor: 2.894

3.  Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? New Insights From the Framingham Offspring Study.

Authors:  Jacquelaine Bartlett; Irene M Predazzi; Scott M Williams; William S Bush; Yeunjung Kim; Stephen Havas; Peter P Toth; Sergio Fazio; Michael Miller
Journal:  Circ Cardiovasc Qual Outcomes       Date:  2016-05-10

Review 4.  Triglycerides: Emerging Targets in Diabetes Care? Review of Moderate Hypertriglyceridemia in Diabetes.

Authors:  Anastasia-Stefania Alexopoulos; Ali Qamar; Kathryn Hutchins; Matthew J Crowley; Bryan C Batch; John R Guyton
Journal:  Curr Diab Rep       Date:  2019-02-26       Impact factor: 4.810

Review 5.  HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology.

Authors:  Robert S Rosenson; H Bryan Brewer; Philip J Barter; Johan L M Björkegren; M John Chapman; Daniel Gaudet; Daniel Seung Kim; Eric Niesor; Kerry-Anne Rye; Frank M Sacks; Jean-Claude Tardif; Robert A Hegele
Journal:  Nat Rev Cardiol       Date:  2017-08-10       Impact factor: 32.419

6.  Dyslipidaemia: Small triumph for fenofibrate therapy in dyslipidaemia.

Authors:  Robert S Rosenson
Journal:  Nat Rev Cardiol       Date:  2017-02-02       Impact factor: 32.419

7.  Plasma apolipoprotein C-III levels, triglycerides, and coronary artery calcification in type 2 diabetics.

Authors:  Arman Qamar; Sumeet A Khetarpal; Amit V Khera; Atif Qasim; Daniel J Rader; Muredach P Reilly
Journal:  Arterioscler Thromb Vasc Biol       Date:  2015-06-11       Impact factor: 8.311

Review 8.  [Severe hypertriglyceridemia : Diagnostics and new treatment principles].

Authors:  U Kassner; M Dippel; E Steinhagen-Thiessen
Journal:  Internist (Berl)       Date:  2017-08       Impact factor: 0.743

9.  Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI Genetics of Lipid Lowering Drugs and Diet Network (GOLDN).

Authors:  Mary K Wojczynski; Laurence D Parnell; Toni I Pollin; Chao Q Lai; Mary F Feitosa; Jeff R O'Connell; Alexis C Frazier-Wood; Quince Gibson; Stella Aslibekyan; Kathy A Ryan; Michael A Province; Hemant K Tiwari; Jose M Ordovas; Alan R Shuldiner; Donna K Arnett; Ingrid B Borecki
Journal:  Metabolism       Date:  2015-07-03       Impact factor: 8.694

Review 10.  Dysfunctional HDL and atherosclerotic cardiovascular disease.

Authors:  Robert S Rosenson; H Bryan Brewer; Benjamin J Ansell; Philip Barter; M John Chapman; Jay W Heinecke; Anatol Kontush; Alan R Tall; Nancy R Webb
Journal:  Nat Rev Cardiol       Date:  2015-09-01       Impact factor: 32.419
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