Qing Li1, Jiang Hong1, Jian Wu2, Zhen-Xing Huang3, Qing-Jie Li2, Rui-Xing Yin2, Quan-Zhen Lin2, Fang Wang4. 1. Department of Internal Medicine, Affiliated Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China. 2. Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. 3. Department of Endocrinology, Institute of the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. 4. Department of Cardiology, Affiliated Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China. Electronic address: wangfang7654@163.com.
Abstract
BACKGROUND: The relation between the ABCB1 and CYP7A1 genes and serum lipid levels and lipid-lowering efficacy of statin treatment is inconsistent. OBJECTIVE: The purpose of this meta-analysis was to explore the associations between the ABCB1 and CYP7A1 genes and serum lipid levels and lipid-lowering efficacy of statin treatment. METHODS: MEDLINE, EMBASE, and the Cochrane Library databases were searched systematically for studies of associations between relevant single nucleotide polymorphisms C3435 T (ABCB1), G2677 A/T (ABCB1), and A-204C (CYP7A1) and serum lipid levels or statin treatment. Associations were assessed in pooled data by calculating mean difference with 95% confidence intervals. RESULTS: Seventeen studies with 4890 patients were included in this meta-analysis. The "AA" group at A-204C (CYP7A1) had lower serum total cholesterol (TC) levels than "AC + CC" group. The "AA" group at A-204C (CYP7A1) had greater reduction in low-density lipoprotein cholesterol (LDL-C) with statin treatment than "AC + CC" group. The "GG" group at G2677 A/T (ABCB1) had less reduction in TC and LDL-C with statin treatment than "non-GG" group. CONCLUSIONS: The A-204C (CYP7A1) polymorphism was associated with the level of TC and the lipid-lowering efficacy of statin treatment in the level of LDL-C. The G2677 A/T (ABCB1) polymorphism was associated with the lipid-lowering efficacy of statin treatment in the levels of LDL-C and TC.
BACKGROUND: The relation between the ABCB1 and CYP7A1 genes and serum lipid levels and lipid-lowering efficacy of statin treatment is inconsistent. OBJECTIVE: The purpose of this meta-analysis was to explore the associations between the ABCB1 and CYP7A1 genes and serum lipid levels and lipid-lowering efficacy of statin treatment. METHODS: MEDLINE, EMBASE, and the Cochrane Library databases were searched systematically for studies of associations between relevant single nucleotide polymorphisms C3435 T (ABCB1), G2677 A/T (ABCB1), and A-204C (CYP7A1) and serum lipid levels or statin treatment. Associations were assessed in pooled data by calculating mean difference with 95% confidence intervals. RESULTS: Seventeen studies with 4890 patients were included in this meta-analysis. The "AA" group at A-204C (CYP7A1) had lower serum total cholesterol (TC) levels than "AC + CC" group. The "AA" group at A-204C (CYP7A1) had greater reduction in low-density lipoprotein cholesterol (LDL-C) with statin treatment than "AC + CC" group. The "GG" group at G2677 A/T (ABCB1) had less reduction in TC and LDL-C with statin treatment than "non-GG" group. CONCLUSIONS: The A-204C (CYP7A1) polymorphism was associated with the level of TC and the lipid-lowering efficacy of statin treatment in the level of LDL-C. The G2677 A/T (ABCB1) polymorphism was associated with the lipid-lowering efficacy of statin treatment in the levels of LDL-C and TC.
Authors: Ross A Carson; Anthony C Rudine; Serena J Tally; Alexis L Franks; Krystle A Frahm; Jacob K Waldman; Neerupma Silswal; Suban Burale; James V Phan; Uma R Chandran; A Paula Monaghan; Donald B DeFranco Journal: PLoS One Date: 2018-05-08 Impact factor: 3.240
Authors: Helga Tryggvadottir; Louise Huzell; Emma Gustbée; Maria Simonsson; Andrea Markkula; Karin Jirström; Carsten Rose; Christian Ingvar; Signe Borgquist; Helena Jernström Journal: Front Oncol Date: 2018-10-12 Impact factor: 6.244