| Literature DB >> 25499881 |
Ya-Li Song1, Fan Wu2, Chao-Chao Zhang2, Guo-Chao Liang2, Guan Zhou2, Jiao-Jiao Yu3.
Abstract
2-(Indole-3-yl)-thiochroman-4-ones were synthesized via ionic liquid and tested for in vitro antifungal activity. The contribution of ionic liquid to Michael addition reaction is significant. Structures of all compounds are elucidated by (1)H NMR, (13)C NMR and HRMS. Most of these compounds showed better antifungal activity than fluconazole. The results suggest that 2-(indole-3-yl)-thiochroman-4-ones would be efficient antifungal agents.Entities:
Keywords: Antifungal activity; Indole; Ionic liquid; Thiochroman-4-one; Thiochromone
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Year: 2014 PMID： 25499881 DOI： 10.1016/j.bmcl.2014.11.056
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823