Literature DB >> 25499805

Complete genome sequence of the actinobacterium Streptomyces glaucescens GLA.O (DSM 40922) consisting of a linear chromosome and one linear plasmid.

Vera Ortseifen1, Anika Winkler2, Andreas Albersmeier2, Sergej Wendler3, Alfred Pühler3, Jörn Kalinowski4, Christian Rückert5.   

Abstract

Here we report the complete and finished genome sequence of Streptomyces glaucescens GLA.O (DSM 40922), a natural producer of the alpha-glucosidase inhibitor acarbose, which is used in the treatment of type-2 diabetes mellitus. The genome of S. glaucescens GLA.O consists of two replicons, the chromosome with a size of 7,453,200bp and a G+C content of 73.0% as well as a plasmid named pSglau1 with a size of 170,574bp and a G+C content of 69.06%.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  5′-hydroxystreptomycin; Acarbose production; Genome sequence; Streptomyces; Tetracenomycin C

Mesh:

Year:  2014        PMID: 25499805     DOI: 10.1016/j.jbiotec.2014.11.036

Source DB:  PubMed          Journal:  J Biotechnol        ISSN: 0168-1656            Impact factor:   3.307


  2 in total

1.  The MalR type regulator AcrC is a transcriptional repressor of acarbose biosynthetic genes in Actinoplanes sp. SE50/110.

Authors:  Timo Wolf; Julian Droste; Tetiana Gren; Vera Ortseifen; Susanne Schneiker-Bekel; Till Zemke; Alfred Pühler; Jörn Kalinowski
Journal:  BMC Genomics       Date:  2017-07-25       Impact factor: 3.969

2.  Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in the Acarbose-Producing Bacterium Actinoplanes sp. SE50/110.

Authors:  Lena Schaffert; Susanne Schneiker-Bekel; Saskia Dymek; Julian Droste; Marcus Persicke; Tobias Busche; David Brandt; Alfred Pühler; Jörn Kalinowski
Journal:  Front Microbiol       Date:  2019-10-29       Impact factor: 5.640

  2 in total

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