Matthew R Hilimire1, Helen S Mayberg2, Paul E Holtzheimer3, James M Broadway4, Nathan A Parks5, Jordan E DeVylder6, Paul M Corballis7. 1. Department of Psychology, College of William and Mary, P.O. Box 8795, Williamsburg, VA 23187-8795, USA. Electronic address: mrhilimire@wm.edu. 2. Emory University, Atlanta, GA, USA. 3. Emory University, Atlanta, GA, USA; Geisel School of Medicine at Dartmouth, Hanover, NH, USA. 4. University of California Santa Barbara, Santa Barbara, CA, USA. 5. University of Arkansas, Fayetteville, AR, USA. 6. Columbia University, New York, NY, USA. 7. University of Auckland, Auckland, New Zealand.
Abstract
BACKGROUND: The cognitive neuropsychological model states that antidepressant treatment alters emotional biases early in treatment, and after this initial change in emotional processing, environmental and social interactions allow for long-term/sustained changes in mood and behavior. OBJECTIVE: Changes in negative self-bias after chronic subcallosal cingulate (SCC) deep brain stimulation (DBS) were investigated with the hypothesis that treatment would lead to changes in emotional biases followed by changes in symptom severity. METHODS: Patients (N = 7) with treatment-resistant depression were assessed at three time points: pre-treatment; after one month stimulation; and after six months stimulation. The P1, P2, P3, and LPP (late positive potential) components of the event-related potential elicited by positive and negative trait adjectives were recorded in both a self-referential task and a general emotion recognition task. RESULTS: Results indicate that DBS reduced automatic attentional bias toward negative words early in treatment, as indexed by the P1 component, and controlled processing of negative words later in treatment, as indexed by the P3 component. Reduction in negative words endorsed as self-descriptive after six months DBS was associated with reduced depression severity after six months DBS. Change in emotional processing may be restricted to the self-referential task. CONCLUSIONS: Together, these results suggest that the cognitive neuropsychological model, developed to explain the time-course of monoamine antidepressant treatment, may also be used as a framework to interpret the antidepressant effects of SCC DBS.
BACKGROUND: The cognitive neuropsychological model states that antidepressant treatment alters emotional biases early in treatment, and after this initial change in emotional processing, environmental and social interactions allow for long-term/sustained changes in mood and behavior. OBJECTIVE: Changes in negative self-bias after chronic subcallosal cingulate (SCC) deep brain stimulation (DBS) were investigated with the hypothesis that treatment would lead to changes in emotional biases followed by changes in symptom severity. METHODS:Patients (N = 7) with treatment-resistant depression were assessed at three time points: pre-treatment; after one month stimulation; and after six months stimulation. The P1, P2, P3, and LPP (late positive potential) components of the event-related potential elicited by positive and negative trait adjectives were recorded in both a self-referential task and a general emotion recognition task. RESULTS: Results indicate that DBS reduced automatic attentional bias toward negative words early in treatment, as indexed by the P1 component, and controlled processing of negative words later in treatment, as indexed by the P3 component. Reduction in negative words endorsed as self-descriptive after six months DBS was associated with reduced depression severity after six months DBS. Change in emotional processing may be restricted to the self-referential task. CONCLUSIONS: Together, these results suggest that the cognitive neuropsychological model, developed to explain the time-course of monoamine antidepressant treatment, may also be used as a framework to interpret the antidepressant effects of SCC DBS.
Authors: Sidney H Kennedy; Peter Giacobbe; Sakina J Rizvi; Franca M Placenza; Yasunori Nishikawa; Helen S Mayberg; Andres M Lozano Journal: Am J Psychiatry Date: 2011-02-01 Impact factor: 18.112
Authors: Ashan Veerakumar; Vineet Tiruvadi; Bryan Howell; Allison C Waters; Andrea L Crowell; Bradley Voytek; Patricio Riva-Posse; Lydia Denison; Justin K Rajendra; Johnathan A Edwards; Kelly R Bijanki; Ki Sueng Choi; Helen S Mayberg Journal: J Neurophysiol Date: 2019-07-17 Impact factor: 2.714
Authors: Lindsay W Victoria; George S Alexopoulos; Irena Ilieva; Aliza T Stein; Matthew J Hoptman; Naib Chowdhury; Matteo Respino; Sarah Shizuko Morimoto; Dora Kanellopoulos; Jimmy N Avari; Faith M Gunning Journal: J Affect Disord Date: 2018-09-11 Impact factor: 4.839