| Literature DB >> 25497988 |
Bui Thi Thuy Luyen1, Bui Huu Tai2, Nguyen Phuong Thao2, Ji Yun Cha3, Hoon Yeon Lee3, Young Mi Lee4, Young Ho Kim5.
Abstract
One new octulosonic acid derivative, chrysannol A (1), along with 17 known compounds (2-18), were isolated from Chrysanthemum indicum flowers. Their structures were determined from 1D NMR, 2D NMR, HR-ESI-MS spectral data, and comparisons with previous reports. The effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor alpha (TNF-α) production by RAW 264.7 cells were investigated. Compound 8 showed the highest inhibition of NO production of 46.09% at a concentration of 10.0μM. Compounds 7, 10, 11, and 16 inhibited TNF-α secretion at all concentration tested (0.4, 2.0, and 10.0μM), with inhibition values ranging from 22.27% to 33.13%. In addition, compound 8 and 9 decrease COX-2 and iNOS protein on Western blot analysis in dose dependent manner.Entities:
Keywords: Anti-inflammation; Chrysannol A; Chrysanthemum indicum; NO; TNF-α
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Year: 2014 PMID： 25497988 DOI： 10.1016/j.bmcl.2014.11.054
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823