| Literature DB >> 25497962 |
Anna Barteselli1, Manolo Casagrande1, Nicoletta Basilico2, Silvia Parapini3, Chiara M Rusconi1, Michele Tonelli4, Vito Boido4, Donatella Taramelli3, Fabio Sparatore4, Anna Sparatore5.
Abstract
A set of novel riminophenazine derivatives has been synthesized and evaluated for in vitro activity against chloroquine-sensitive (CQ-S) and chloroquine-resistant (CQ-R) strains of Plasmodium falciparum and against different species of Leishmania promastigotes. Most of the new compounds inhibited the growth of Leishmania promastigotes as well as CQ-S and CQ-R strains of P. falciparum with IC50 in submicromolar range, resulting in the best cases 1-2 orders of magnitude more potent than the parent compound clofazimine.Entities:
Keywords: Antileishmanial activity; Antiplasmodial activity; Clofazimine; Clofazimine analogs; Pyrrolizidinyl-alkyliminophenazine derivatives; Quinolizidinyl-alkyliminophenazine derivatives
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Year: 2014 PMID： 25497962 DOI： 10.1016/j.bmc.2014.11.028
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641