Sahar A Ibrahim Hammouda1, Om Alsaad Farouk Abd Al-Halim2, Ahmed M Mohamadin3. 1. Faculty of Applied Medical Sciences, Clinical Nutrition Department, Taibah University, Saudi Arabia. 2. Faculty of Applied Medical Sciences, Nursing Department, Taibah University, Saudi Arabia. 3. Deanery of Academic Services, Chemistry for Health Sciences Department, Taibah University, Saudi Arabia.
Abstract
BACKGROUND/ OBJECTIVES: Various studies have linked vitamin deficiencies in early pregnancy with birth defects. The objective of this study was to identify the relationship between micronutrient deficiency and congenital malformations (CM). SUBJECTS AND METHODS: There were 1,180 healthy, first-trimester pregnant Saudi-Arabian females selected from the antenatal care clinics of two hospitals and 21 health care centers located all over the city. Their full medical history, clinical examination, anthropometry, and various laboratory analyses were completed. RESULTS: Forty-eight infants were born with CM. The serum concentrations of the analyzed nutrients (selenium, zinc, magnesium, and vitamins A, E, B12, and folic acid) were significantly lower in mothers of infants with CM compared to the mothers of infants without CM. In comparison, the serum totals of homocysteine (tHcy) levels were significantly higher among the CM group. CONCLUSION: This study highlights the association of CM with the deficiency of certain vitamins and minerals among pregnant women.
BACKGROUND/ OBJECTIVES: Various studies have linked vitamin deficiencies in early pregnancy with birth defects. The objective of this study was to identify the relationship between micronutrient deficiency and congenital malformations (CM). SUBJECTS AND METHODS: There were 1,180 healthy, first-trimester pregnant Saudi-Arabian females selected from the antenatal care clinics of two hospitals and 21 health care centers located all over the city. Their full medical history, clinical examination, anthropometry, and various laboratory analyses were completed. RESULTS: Forty-eight infants were born with CM. The serum concentrations of the analyzed nutrients (selenium, zinc, magnesium, and vitamins A, E, B12, and folic acid) were significantly lower in mothers of infants with CM compared to the mothers of infants without CM. In comparison, the serum totals of homocysteine (tHcy) levels were significantly higher among the CM group. CONCLUSION: This study highlights the association of CM with the deficiency of certain vitamins and minerals among pregnant women.
Authors: Sabina Bastos Maia; Maria de Fátima Costa Caminha; Suzana Lins da Silva; Alex Sandro Rolland Souza; Camila Carvalho Dos Santos; Malaquias Batista Filho Journal: Nutrients Date: 2018-09-09 Impact factor: 5.717
Authors: Rami H Al-Rifai; Nasloon Ali; Esther T Barigye; Amal H I Al Haddad; Fatima Al-Maskari; Tom Loney; Luai A Ahmed Journal: Syst Rev Date: 2020-01-16