Literature DB >> 25497704

Fear extinction in 17 day old rats is dependent on metabotropic glutamate receptor 5 signaling.

Despina E Ganella1, Pushbalela Thangaraju2, Andrew J Lawrence3, Jee Hyun Kim4.   

Abstract

We used pharmacological modulation of the mGlu5 receptor to investigate its role in the extinction of conditioned fear throughout development. In postnatal day (P) 17 rats, the positive allosteric modulator CDPPB facilitated, while the negative allosteric modulator MTEP impaired extinction. These drugs had no such effects on P24 or adult rats. These results establish a changing importance of mGlu5 in extinction of conditioned fear at distinct stages of development.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  CDPPB; Development; Extinction; Fear; MTEP; Mglu5

Mesh：

Substances：

Year:  2014        PMID： 25497704     DOI： 10.1016/j.bbr.2014.12.010

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  7 in total

Review 1.  Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias.

Authors:  K Sengmany; K J Gregory
Journal:  Br J Pharmacol       Date:  2015-11-11       Impact factor: 8.739

2.  Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.

Authors:  Kathy Sengmany; Junaid Singh; Gregory D Stewart; P Jeffrey Conn; Arthur Christopoulos; Karen J Gregory
Journal:  Neuropharmacology       Date:  2016-07-05       Impact factor: 5.250

3.  A dissociation between recognition and reactivation: The renewal effect at 3 months of age.

Authors:  Kimberly Cuevas; Amy E Learmonth; Carolyn Rovee-Collier
Journal:  Dev Psychobiol       Date:  2015-09-23       Impact factor: 3.038

4.  The metabotropic glutamate 5 receptor is necessary for extinction of cocaine-associated cues.

Authors:  Christina J Perry; Felicia Reed; Isabel C Zbukvic; Jee Hyun Kim; Andrew J Lawrence
Journal:  Br J Pharmacol       Date:  2016-02-18       Impact factor: 8.739

5.  Aripiprazole Facilitates Extinction of Conditioned Fear in Adolescent Rats.

Authors:  Despina E Ganella; Liubov Lee-Kardashyan; Sophia J Luikinga; Danny L D Nguyen; Heather B Madsen; Isabel C Zbukvic; Russell Coulthard; Andrew J Lawrence; Jee Hyun Kim
Journal:  Front Behav Neurosci       Date:  2017-05-09       Impact factor: 3.558

6.  Prefrontal Dopaminergic Mechanisms of Extinction in Adolescence Compared to Adulthood in Rats.

Authors:  Isabel C Zbukvic; Chun Hui J Park; Despina E Ganella; Andrew J Lawrence; Jee Hyun Kim
Journal:  Front Behav Neurosci       Date:  2017-02-22       Impact factor: 3.558

7.  Juvenile female rats, but not male rats, show renewal, reinstatement, and spontaneous recovery following extinction of conditioned fear.

Authors:  Chun Hui J Park; Despina E Ganella; Jee Hyun Kim
Journal:  Learn Mem       Date:  2017-11-15       Impact factor: 2.460
  7 in total

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