Michal Král1, Daniel Šaňák1, Tomáš Veverka1, Martin Hutyra2, David Vindiš2, Andrea Bártková1, Anna Kunčarová1, Tomáš Dorňák1, Eva Čecháková3, Roman Herzig4, Kateřina Langová5, Petr Kaňovský4, David Školoudík6. 1. Comprehensive Stroke Center, Department of Neurology, University Hospital, Olomouc, Czech Republic. 2. Department of Internal Medicine I - Cardiology, University Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic. 3. Department of Radiology, University Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic. 4. Department of Neurology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic. 5. Department of Biophysics, Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University, Olomouc, Czech Republic. 6. Department of Neurology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic; Department of Nursing, Faculty of Health Science, Palacký University, Olomouc, Czech Republic. Electronic address: skoloudik@hotmail.com.
Abstract
BACKGROUND: The troponin T (cTnT) is frequently elevated in acute ischemic stroke (AIS) patients. However, the relationship, if any, between the cTnT level and brain infarction remains to be established. The aim was to investigate the possible correlation between the location and volume of brain infarction and the cardiac cTnT serum level in AIS patients. METHODS: The study consisted of consecutive AIS patients admitted within 12h of stroke onset. The location and volume of the acute ischemic lesion was assessed with magnetic resonance imaging. Standard laboratory tests, including cTnT and repeated electrocardiograms, were performed at admission and after 4h. Correlations between the cTnT level and the location and volume of brain infarction and baseline parameters were tested with a Spearman correlation coefficient. Univariate and multiple logistic regression analysis (LRA) were used to determine the possible predictors of cTnT elevation. RESULTS: Out of the 200 enrolled patients, elevated cTnT was present in 71 (36%). No correlation was found between the cTnT serum levels and the location (P>0.05) nor volume of brain infarction (r=0.05, P=0.48). LRA identified creatinine (OR: 1.26 per 10μmol/L increase; 95% CI: 1.043-1.524), NT-proBNP (OR: 1.05 per 100μg/L increase; 95% CI: 1.018-1.093) and male gender (OR: 3.674; 95% CI: 1.025-13.164) as significant independent predictors of pathological elevation of cTnT. CONCLUSIONS: Although elevated cTnT serum level is relatively frequent in AIS patients within the first 12h of stroke onset, it is not related to the location or volume of brain infarction. CLINICAL TRIAL REGISTRATION: http://www.clinicaltrials.gov (No. NCT01541163).
BACKGROUND: The troponin T (cTnT) is frequently elevated in acute ischemic stroke (AIS) patients. However, the relationship, if any, between the cTnT level and brain infarction remains to be established. The aim was to investigate the possible correlation between the location and volume of brain infarction and the cardiac cTnT serum level in AISpatients. METHODS: The study consisted of consecutive AISpatients admitted within 12h of stroke onset. The location and volume of the acute ischemic lesion was assessed with magnetic resonance imaging. Standard laboratory tests, including cTnT and repeated electrocardiograms, were performed at admission and after 4h. Correlations between the cTnT level and the location and volume of brain infarction and baseline parameters were tested with a Spearman correlation coefficient. Univariate and multiple logistic regression analysis (LRA) were used to determine the possible predictors of cTnT elevation. RESULTS: Out of the 200 enrolled patients, elevated cTnT was present in 71 (36%). No correlation was found between the cTnT serum levels and the location (P>0.05) nor volume of brain infarction (r=0.05, P=0.48). LRA identified creatinine (OR: 1.26 per 10μmol/L increase; 95% CI: 1.043-1.524), NT-proBNP (OR: 1.05 per 100μg/L increase; 95% CI: 1.018-1.093) and male gender (OR: 3.674; 95% CI: 1.025-13.164) as significant independent predictors of pathological elevation of cTnT. CONCLUSIONS: Although elevated cTnT serum level is relatively frequent in AISpatients within the first 12h of stroke onset, it is not related to the location or volume of brain infarction. CLINICAL TRIAL REGISTRATION: http://www.clinicaltrials.gov (No. NCT01541163).
Authors: Kai Liesirova; Eugenio Abela; Thomas Pilgrim; Laura Bickel; Thomas Meinel; Julia Meisterernst; Verma Rajeev; Hakan Sarikaya; Mirjam R Heldner; Tomas Dobrocky; Erick Siqueira; Marwan El-Koussy; Urs Fischer; Jan Gralla; Marcel Arnold; Heinrich P Mattle; Kety Hsieh; Simon Jung Journal: PLoS One Date: 2018-12-31 Impact factor: 3.240