| Literature DB >> 25497347 |
Peter Bai1, Lilla Nagy2, Tamás Fodor2, Lucas Liaudet3, Pal Pacher4.
Abstract
Mitochondria are essential in cellular stress responses. Mitochondrial output to environmental stress is a major factor in metabolic adaptation and is regulated by a complex network of energy and nutrient sensing proteins. Activation of poly(ADP-ribose) polymerases (PARPs) has been known to impair mitochondrial function; however, our view of PARP-mediated mitochondrial dysfunction and injury has only recently fundamentally evolved. In this review, we examine our current understanding of PARP-elicited mitochondrial damage, PARP-mediated signal transduction pathways, transcription factors that interact with PARPs and govern mitochondrial biogenesis, as well as mitochondrial diseases that are mediated by PARPs. With PARP activation emerging as a common underlying mechanism in numerous pathologies, a better understanding the role of various PARPs in mitochondrial regulation may help open new therapeutic avenues.Entities:
Keywords: AMP activated kinase; NAD(+); Sirtuin; hypoxia-inducible factor; nuclear respiratory factor; poly(ADP-ribose) polymerase
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Year: 2014 PMID： 25497347 DOI： 10.1016/j.tem.2014.11.003
Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015