Literature DB >> 2549714

The adeno-associated virus Rep78 gene inhibits cellular transformation induced by bovine papillomavirus.

P L Hermonat1.   

Abstract

Adeno-associated virus type 2 (AAV) is a helper dependent parvovirus which can inhibit the oncogenic and transforming potential of its helper viruses: adenoviruses (Ad) and herpesviruses. Here we have assayed AAV's ability to inhibit cellular transformation induced by bovine papillomavirus type 1 (BPV-1), a member of another family of DNA viruses. AAV was able to markedly inhibit BPV-1-induced transformation of contact-inhibited murine fibroblasts either by infection with virus particles or by DNA transfection. This inhibition was mapped to the full-length, unspliced, rep gene product, Rep78, of AAV. DNA replication by AAV or by BPV-1 was not required for inhibition of transformation to take place.

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Year:  1989        PMID： 2549714     DOI： 10.1016/0042-6822(89)90127-x

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  45 in total

1.  Factors affecting the terminal resolution site endonuclease, helicase, and ATPase activities of adeno-associated virus type 2 Rep proteins.

Authors:  J Wu; M D Davis; R A Owens
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

2.  Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins.

Authors:  J Hermanns; A Schulze; P Jansen-Db1urr; J A Kleinschmidt; R Schmidt; H zur Hausen
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

Review 3.  Parvovirus replication.

Authors:  K I Berns
Journal:  Microbiol Rev       Date:  1990-09

4.  HPV E1 up-regulates replication-related biochemistries of AAV Rep78.

Authors:  Sarmistha Bandyopadhyay; Maohua Cao; Yong Liu; Paul L Hermonat
Journal:  Virology       Date:  2010-04-07       Impact factor: 3.616

5.  Origin of adeno-associated virus DNA replication is a target of carcinogen-inducible DNA amplification.

Authors:  A O Yalkinoglu; H Zentgraf; U Hübscher
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

6.  Influence of adeno-associated virus on adherence and growth properties of normal cells.

Authors:  U Bantel-Schaal; M Stöhr
Journal:  J Virol       Date:  1992-02       Impact factor: 5.103

7.  Inhibition of PrKX, a novel protein kinase, and the cyclic AMP-dependent protein kinase PKA by the regulatory proteins of adeno-associated virus type 2.

Authors:  J A Chiorini; B Zimmermann; L Yang; R H Smith; A Ahearn; F Herberg; R M Kotin
Journal:  Mol Cell Biol       Date:  1998-10       Impact factor: 4.272

8.  The Rep68 protein of adeno-associated virus type 2 stimulates expression of the platelet-derived growth factor B c-sis proto-oncogene.

Authors:  R S Wonderling; R A Owens
Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

9.  Characterization of cell lines that inducibly express the adeno-associated virus Rep proteins.

Authors:  Q Yang; F Chen; J P Trempe
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

10.  Adeno-associated virus Rep protein inhibits human immunodeficiency virus type 1 production in human cells.

Authors:  B A Antoni; A B Rabson; I L Miller; J P Trempe; N Chejanovsky; B J Carter
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103
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