Literature DB >> 25497131

Synthesis, anticandidal activity of N(3)-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic amide derivatives--novel inhibitors of glucosamine-6-phosphate synthase.

Dorota Pawlak1, Magdalena Stolarska1, Marek Wojciechowski1, Ryszard Andruszkiewicz2.   

Abstract

Novel FMDP amides 4-6 have been synthesized and tested against Candida strains. The anticandidal activity has been confined only to Candida albicans. Anticandidal activity of the tested amides has correlated with their inhibitory activity of glucosamine-6-phosphate synthase in cell free extract from C. albicans.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Antifungal activity; FMDP analogs; Glucosamine-6-phosphate synthase inhibitors; Molecular modeling

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Year:  2014        PMID： 25497131     DOI： 10.1016/j.ejmech.2014.12.007

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  1 in total

1.  Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics - synthesis and properties.

Authors:  Joanna Stefaniak; Michał G Nowak; Marek Wojciechowski; Sławomir Milewski; Andrzej S Skwarecki
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756
  1 in total

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