| Literature DB >> 25495388 |
Jian-Jun Dai1, Wen-Tao Xu, Ya-Dong Wu, Wen-Man Zhang, Ying Gong, Xia-Ping He, Xin-Qing Zhang, Hua-Jian Xu.
Abstract
Silver-catalyzed C(sp(2))-H functionalization/C-O cyclization has been developed. The scalable reaction proceeds at room temperature in an open flask. The present method exhibits good functional-group compatibility because of the mild reaction conditions. Using a AgNO3 catalyst and a (NH4)2S2O8 oxidant in CH2Cl2/H2O solvent, various lactones are obtained in good to excellent yields. A kinetic isotope effect (KIE) study indicates that the reaction may occur via a radical process.Entities:
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Year: 2014 PMID： 25495388 DOI： 10.1021/jo5024238
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354