| Literature DB >> 2549466 |
N P Wiklund1, C U Wiklund, A Ohlén, L E Gustafsson.
Abstract
The effect of endothelin on cholinergic neuroeffector transmission in guinea pig ileum was investigated. Endothelin was shown to inhibit the nerve-induced contractions and concomitantly to increase the basal muscle tone. Furthermore, endothelin inhibited the nerve-induced release of [3H]acetylcholine whereas the contractile response to exogenous acetylcholine was enhanced. In conclusion, our findings suggest that endothelin is a modulator of cholinergic neuroeffector transmission in guinea pig ileum with possible action via both inhibitory prejunctional and stimulatory postjunctional mechanisms.Entities:
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Year: 1989 PMID： 2549466 DOI： 10.1016/0304-3940(89)90557-0
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046