Manli Zhao1, Lunzhong Zhang2, Zeying Wang2, Xianglei Wang2, Yuyong Wang2, Hongyu Wei2, Ruihua Li3, Yifeng Du4. 1. Department of Neurology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, PR China Weifang Traditional Chinese Medicine Hospital, Weifang 261041, Shandong, PR China. 2. Weifang Traditional Chinese Medicine Hospital, Weifang 261041, Shandong, PR China. 3. Laiwu People's Hospital, Laiwu 271100, Shandong, PR China. 4. Department of Neurology, Shandong Provincial Hospital, Jinan 250021, Shandong, PR China yifengdu2013@163.com.
Abstract
BACKGROUND: Progressive cerebral infarction is one of the leading causes of high disability and lethality for stroke patients. However, the association between progression of BP changes and cerebral infarction is not currently well understood. METHODS: We analyzed the dynamic changes in the BP of patients with acute ischemic stroke and explored the correlation between BP change and cerebral infarction progression. RESULTS: 30.9% (30/97) of the patients investigated developed to progressive cerebral infarction 17-141 h after admission. The percentage of patients with a long history of hypertension was significantly higher in the progressive group than in the non-progressive group. The mean systolic BP of the patients 16 h to 5 d after admission was also much higher in the progressive group. A greater abnormality of circadian blood pressure was also observed among patients in the progressive group. CONCLUSIONS: Hypertension history of more than 5 years is an important risk factor for progressive cerebral infarction. Both the elevation of systolic blood pressure 16 h to 5 d after admission and abnormal circadian blood pressure are associated with the disease progression.
BACKGROUND: Progressive cerebral infarction is one of the leading causes of high disability and lethality for strokepatients. However, the association between progression of BP changes and cerebral infarction is not currently well understood. METHODS: We analyzed the dynamic changes in the BP of patients with acute ischemic stroke and explored the correlation between BP change and cerebral infarction progression. RESULTS: 30.9% (30/97) of the patients investigated developed to progressive cerebral infarction 17-141 h after admission. The percentage of patients with a long history of hypertension was significantly higher in the progressive group than in the non-progressive group. The mean systolic BP of the patients 16 h to 5 d after admission was also much higher in the progressive group. A greater abnormality of circadian blood pressure was also observed among patients in the progressive group. CONCLUSIONS:Hypertension history of more than 5 years is an important risk factor for progressive cerebral infarction. Both the elevation of systolic blood pressure 16 h to 5 d after admission and abnormal circadian blood pressure are associated with the disease progression.
Authors: Ruo-Shi Zang; Hong Zhang; Yan Xu; Sheng-Ming Zhang; Xi Liu; Jing Wang; Yong-Zhe Gao; Min Shu; Bin Mei; Hua-Gang Li Journal: Transl Neurosci Date: 2016-08-22 Impact factor: 1.757