Seyhan Yilmaz1, Eray Aksoy2, Suat Doganci3, Adnan Yalcinkaya2, Adem I Diken2, Kerim Cagli2. 1. Department of Cardiovascular Surgery, Hitit University Corum Education and Research Hospital, Turkey drlabarna@gmail.com. 2. Department of Cardiovascular Surgery, Hitit University Corum Education and Research Hospital, Turkey. 3. Department of Cardiovascular Surgery, Gulhane Medical Military Academy, Turkey.
Abstract
STUDY: We report our results on a case series of 19 patients receiving platelet-rich plasma application in treatment of patients with chronic unhealing venous leg ulcers. MATERIAL AND METHODS: There were 16 males and three females with a mean age of 38.55 ± 16.46 years. Planimetric size measurements were performed and pain was tested throughout the treatment period. Follow-up was made in seven-day periods. Patients received 5 ml of platelet-rich plasma for each 5 cm(2) of the wound surface with half of the amount being injected 1-2 mm deep into the wound and the wound surface was covered with the remaining half. RESULTS: Complete wound healing occurred in 18 of 19 patients (94.7%) within a mean of 4.82 ± 2.16 week. There were significant reductions in wound area among all consecutive measurements except for first week. A significant reduction in wound volume was apparent even in first week and sustained among consecutive measurements. CONCLUSION: Platelet-rich plasma seems effective in terms of promoting healing of venous leg ulcers. Improvement in wound depth was slightly more prominent than that in wound area, indicating a potential role of platelet-rich plasma especially in deep venous ulcers.
STUDY: We report our results on a case series of 19 patients receiving platelet-rich plasma application in treatment of patients with chronic unhealing venous leg ulcers. MATERIAL AND METHODS: There were 16 males and three females with a mean age of 38.55 ± 16.46 years. Planimetric size measurements were performed and pain was tested throughout the treatment period. Follow-up was made in seven-day periods. Patients received 5 ml of platelet-rich plasma for each 5 cm(2) of the wound surface with half of the amount being injected 1-2 mm deep into the wound and the wound surface was covered with the remaining half. RESULTS: Complete wound healing occurred in 18 of 19 patients (94.7%) within a mean of 4.82 ± 2.16 week. There were significant reductions in wound area among all consecutive measurements except for first week. A significant reduction in wound volume was apparent even in first week and sustained among consecutive measurements. CONCLUSION: Platelet-rich plasma seems effective in terms of promoting healing of venous leg ulcers. Improvement in wound depth was slightly more prominent than that in wound area, indicating a potential role of platelet-rich plasma especially in deep venous ulcers.