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Literature DB >> 25491407

Chemical shift assignments of mouse HOXD13 DNA binding domain bound to duplex DNA.

Matthew Turner¹, Yonghong Zhang¹, Hanqian L Carlson², H Scott Stadler^2,3, James B Ames⁴.

Abstract

The homeobox gene (Hoxd13) codes for a transcription factor protein that binds to AT-rich DNA sequences and controls expression of proteins that control embryonic morphogenesis. We report NMR chemical shift assignments of mouse Hoxd13 DNA binding domain bound to an 11-residue DNA duplex (BMRB No. 25133).

Entities: Chemical Disease Gene Species

Keywords: DNA binding domain; Duplex DNA; HOXD13; Homeodomain; NMR

Mesh：

Substances：

Year: 2014 PMID： 25491407 PMCID： PMC4465062 DOI： 10.1007/s12104-014-9589-4

Source DB: PubMed Journal: Biomol NMR Assign ISSN： 1874-270X Impact factor: 0.746

16 in total

1. A HOXA13 allele with a missense mutation in the homeobox and a dinucleotide deletion in the promoter underlies Guttmacher syndrome.

Authors: Jeffrey W Innis; Frances R Goodman; Chiara Bacchelli; Thomas M Williams; Douglas P Mortlock; Praveen Sateesh; Peter J Scambler; Wendy McKinnon; Alan E Guttmacher
Journal: Hum Mutat Date: 2002-05 Impact factor: 4.878

2. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation.

Authors: D E Piper; A H Batchelor; C P Chang; M L Cleary; C Wolberger
Journal: Cell Date: 1999-02-19 Impact factor: 41.582

3. The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development.

Authors: P Dollé; J C Izpisúa-Belmonte; E Boncinelli; D Duboule
Journal: Mech Dev Date: 1991-12 Impact factor: 1.882

4. Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13.

Authors: Y Muragaki; S Mundlos; J Upton; B R Olsen
Journal: Science Date: 1996-04-26 Impact factor: 47.728

Review 5. Chemical shifts as a tool for structure determination.

Authors: D S Wishart; B D Sykes
Journal: Methods Enzymol Date: 1994 Impact factor: 1.600

Review 6. Hox genes in vertebrate development.

Authors: R Krumlauf
Journal: Cell Date: 1994-07-29 Impact factor: 41.582

Chemical shift assignments of mouse HOXD13 DNA binding domain bound to duplex DNA.

1. A HOXA13 allele with a missense mutation in the homeobox and a dinucleotide deletion in the promoter underlies Guttmacher syndrome.

2. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation.

3. The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development.

4. Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13.

Review 5. Chemical shifts as a tool for structure determination.

Review 6. Hox genes in vertebrate development.

7. Mutation of HOXA13 in hand-foot-genital syndrome.

8. Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod.

9. HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis.

Review 10. Limb malformations and the human HOX genes.

1. Chemical shift assignments of the C-terminal EF-hand domain of α-actinin-1.

2. Genome-Wide Binding of Posterior HOXA/D Transcription Factors Reveals Subgrouping and Association with CTCF.