A highly selective and sensitive probe for Cu2+ based on rhodamine-pyridazine conjugate and its application.

A naked-eye fluorescent chemodosimeter based on rhodamine-pyridazine conjugate L was synthesized and characterized. L exhibited high selectivity and excellent sensitivity in both absorbance and fluorescence detection of Cu(2+) in aqueous solution with a broad pH span (1-10). The detection limit of the probe was shown to be up to 0.336 ppm. A simple paper test-strip system for the rapid monitoring of Cu(2+) was developed, indicating its convenient use in environmental samples. Furthermore, fluorescence imaging experiments of Cu(2+) in living MGC803 cells demonstrated its value of practical applications in biological systems.