Literature DB >> 25491343

The origin of life: a problem of history, chemistry, and evolution.

Wentao Ma1.   

Abstract

The origin of life is a field full of controversies, not only because of our vague understanding concerning the relevant issues, but also, perhaps more often, owing to our dim conceptual framework throughout the whole field. To improve this situation, an in-depth conceptual dissection is presented here. It is elucidated that, at its core, the origin of life has three aspects. The facts involved in the process are taken as the historical aspect, which is destined to be uncertain and often irrelevant to debate regarding details. The rules involved include two distinct aspects: chemical mechanisms operated in the whole process, while evolutionary mechanisms joined in only after the emergence of the first Darwinian entities - and then accounted for the subsequent buildup of complexity (this cannot be explained solely by natural selection). Basically, we can ask about the possibility of any assumed event in the origin of life: 'Is it evolutionarily plausible, chemically feasible, and historically likely?' Clues from any of the three aspects may be quite valuable in directing our explorations on the other two. This conceptual dissection provides a clearer context for the field, which may even be more useful than any sort of specific research.
Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich.

Keywords:  Darwinian entity; Essence of life; Natural selection; Prebiotic evolution; RNA World

Mesh:

Year:  2014        PMID: 25491343     DOI: 10.1002/cbdv.201400188

Source DB:  PubMed          Journal:  Chem Biodivers        ISSN: 1612-1872            Impact factor:   2.408


  7 in total

1.  Exploration of RNA Sequence Space in the Absence of a Replicase.

Authors:  Madhan R Tirumalai; Quyen Tran; Maxim Paci; Dimple Chavan; Anuradha Marathe; George E Fox
Journal:  J Mol Evol       Date:  2018-05-11       Impact factor: 2.395

2.  Protocells: at the interface of life and non-life.

Authors:  Wentao Ma; Yu Feng
Journal:  Life (Basel)       Date:  2015-02-09

3.  What Does "the RNA World" Mean to "the Origin of Life"?

Authors:  Wentao Ma
Journal:  Life (Basel)       Date:  2017-11-29

4.  Tag mechanism as a strategy for the RNA replicase to resist parasites in the RNA world.

Authors:  Sanmao Wu; Chunwu Yu; Wentao Zhang; Shaolin Yin; Yong Chen; Yu Feng; Wentao Ma
Journal:  PLoS One       Date:  2017-03-02       Impact factor: 3.240

5.  From molecular to cellular form: modeling the first major transition during the arising of life.

Authors:  Shaolin Yin; Yong Chen; Chunwu Yu; Wentao Ma
Journal:  BMC Evol Biol       Date:  2019-04-03       Impact factor: 3.260

6.  The origin of biological homochirality along with the origin of life.

Authors:  Yong Chen; Wentao Ma
Journal:  PLoS Comput Biol       Date:  2020-01-08       Impact factor: 4.475

7.  The automatic parameter-exploration with a machine-learning-like approach: Powering the evolutionary modeling on the origin of life.

Authors:  Yuzhen Liang; Chunwu Yu; Wentao Ma
Journal:  PLoS Comput Biol       Date:  2021-12-29       Impact factor: 4.475

  7 in total

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