Literature DB >> 25490544

Step-emulsification in a microfluidic device.

Z Li1, A M Leshansky, S Metais, L M Pismen, P Tabeling.   

Abstract

We present a comprehensive study of the step-emulsification process for high-throughput production of colloidal monodisperse droplets. The 'microfluidic step emulsifier' combines a shallow microchannel operating with two co-flowing immiscible fluids and an abrupt (step-like) opening to a deep and wide reservoir. Based on Hele-Shaw hydrodynamics, we determine the quasi-static shape of the fluid interface prior to transition to oscillatory step-emulsification at low capillary numbers. The theoretically derived transition threshold yields an excellent agreement with experimental data. A closed-form expression for the size of the droplets generated in the step-emulsification regime and derived using geometric arguments also shows a very good agreement with the experiment.

Year:  2015        PMID: 25490544     DOI: 10.1039/c4lc01289e

Source DB:  PubMed          Journal:  Lab Chip        ISSN: 1473-0189            Impact factor:   6.799


  15 in total

Review 1.  Droplet microfluidics for high-sensitivity and high-throughput detection and screening of disease biomarkers.

Authors:  Aniruddha M Kaushik; Kuangwen Hsieh; Tza-Huei Wang
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2018-05-24

2.  Wetting controls of droplet formation in step emulsification.

Authors:  Maximilian L Eggersdorfer; Hansjörg Seybold; Alessandro Ofner; David A Weitz; André R Studart
Journal:  Proc Natl Acad Sci U S A       Date:  2018-09-05       Impact factor: 11.205

3.  High aspect ratio induced spontaneous generation of monodisperse picolitre droplets for digital PCR.

Authors:  Xiaonan Xu; Haojun Yuan; Ruyuan Song; Miao Yu; Ho Yin Chung; Youmin Hou; Yuhe Shang; Hongbo Zhou; Shuhuai Yao
Journal:  Biomicrofluidics       Date:  2018-01-02       Impact factor: 2.800

Review 4.  Scaling up the throughput of microfluidic droplet-based materials synthesis: A review of recent progress and outlook.

Authors:  Jingyu Wu; Sagar Yadavali; Daeyeon Lee; David A Issadore
Journal:  Appl Phys Rev       Date:  2021-09       Impact factor: 19.527

Review 5.  Microfluidic fabrication of microparticles for biomedical applications.

Authors:  Wen Li; Liyuan Zhang; Xuehui Ge; Biyi Xu; Weixia Zhang; Liangliang Qu; Chang-Hyung Choi; Jianhong Xu; Afang Zhang; Hyomin Lee; David A Weitz
Journal:  Chem Soc Rev       Date:  2018-07-30       Impact factor: 54.564

Review 6.  Discovery in Droplets.

Authors:  Alexander K Price; Brian M Paegel
Journal:  Anal Chem       Date:  2015-11-20       Impact factor: 6.986

7.  3D-glass molds for facile production of complex droplet microfluidic chips.

Authors:  Miguel Tovar; Thomas Weber; Sundar Hengoju; Andrea Lovera; Anne-Sophie Munser; Oksana Shvydkiv; Martin Roth
Journal:  Biomicrofluidics       Date:  2018-04-03       Impact factor: 2.800

8.  Numerical Investigation of Cell Encapsulation for Multiplexing Diagnostic Assays Using Novel Centrifugal Microfluidic Emulsification and Separation Platform.

Authors:  Yong Ren; Wallace Woon Fong Leung
Journal:  Micromachines (Basel)       Date:  2016-01-25       Impact factor: 2.891

9.  Scalable Production of Monodisperse Functional Microspheres by Multilayer Parallelization of High Aspect Ratio Microfluidic Channels.

Authors:  Casper Ho Yin Chung; Binbin Cui; Ruyuan Song; Xin Liu; Xiaonan Xu; Shuhuai Yao
Journal:  Micromachines (Basel)       Date:  2019-09-10       Impact factor: 2.891

Review 10.  Microfluidics Mediated Production of Foams for Biomedical Applications.

Authors:  Ilham Maimouni; Cesare M Cejas; Janine Cossy; Patrick Tabeling; Maria Russo
Journal:  Micromachines (Basel)       Date:  2020-01-12       Impact factor: 2.891

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